The sialic acid-dependent nematocyst discharge process in relation to its physical-chemical properties is a role model for nanomedical diagnostic and therapeutic tools
Artikel i vetenskaplig tidskrift, 2019

Formulas derived from theoretical physics provide important insights about the nematocyst discharge process of Cnidaria (Hydra, jellyfishes, box-jellyfishes and sea-anemones). Our model description of the fastest process in living nature raises and answers questions related to the material properties of the cell- and tubule-walls of nematocysts including their polysialic acid (polySia) dependent target function. Since a number of tumor-cells, especially brain-tumor cells such as neuroblastoma tissues carry the polysaccharide chain polySia in similar concentration as fish eggs or fish skin, it makes sense to use these findings for new diagnostic and therapeutic approaches in the field of nanomedicine. Therefore, the nematocyst discharge process can be considered as a bionic blue-print for future nanomedical devices in cancer diagnostics and therapies. This approach is promising because the physical background of this process can be described in a sufficient way with formulas presented here. Additionally, we discuss biophysical and biochemical experiments which will allow us to define proper boundary conditions in order to support our theoretical model approach. PolySia glycans occur in a similar density on malignant tumor cells than on the cell surfaces of Cnidarian predators and preys. The knowledge of the polySia-dependent initiation of the nematocyst discharge process in an intact nematocyte is an essential prerequisite regarding the further development of target-directed nanomedical devices for diagnostic and therapeutic purposes. The theoretical description as well as the computationally and experimentally derived results about the biophysical and biochemical parameters can contribute to a proper design of anti-tumor drug ejecting vessels which use a stylet-tubule system. Especially, the role of nematogalectins is of interest because these bridging proteins contribute as well as special collagen fibers to the elastic band properties. The basic concepts of the nematocyst discharge process inside the tubule cell walls of nematocysts were studied in jellyfishes and in Hydra which are ideal model organisms. Hydra has already been chosen by Alan Turing in order to figure out how the chemical basis of morphogenesis can be described in a fundamental way. This encouraged us to discuss the action of nematocysts in relation to morphological aspects and material requirements. Using these insights, it is now possible to discuss natural and artificial nematocyst-like vessels with optimized properties for a diagnostic and therapeutic use, e.g., in neurooncology. We show here that crucial physical parameters such as pressure thresholds and elasticity properties during the nematocyst discharge process can be described in a consistent and satisfactory way with an impact on the construction of new nanomedical devices.

Polysialic acid (polySia)

Theoretical model

Nanomedical devices

Nematocyst discharge process

Nematogalectin

Författare

Ruiyan Zhang

Liaocheng University

Li Jin

Liaocheng University

Ning Zhang

Liaocheng University

RI-B-NT Research Institute of Bioinformatics and Nanotechnology

Athanasios K. Petridis

Heinrich Heine Universität Düsseldorf

Thomas Eckert

RISCC-Research Institute for Scientific Computing and Consulting

Hochschule Fresenius

Justus Liebig University Giessen

Georgios Scheiner-Bobis

Justus Liebig University Giessen

Martin Bergmann

Justus Liebig University Giessen

Axel J. Scheidig

Christian-Albrechts-Universität zu Kiel

Roland Schauer

Christian-Albrechts-Universität zu Kiel

Mingdi Yan

University of Massachusetts Lowell

Samurdhi A. Wijesundera

University of Massachusetts Lowell

Bengt Nordén

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Barun K. Chatterjee

Bose Institute

Hans Christian Siebert

RI-B-NT Research Institute of Bioinformatics and Nanotechnology

Marine Drugs

1660-3397 (ISSN)

Vol. 17 8 469

Ämneskategorier

Cell- och molekylärbiologi

Annan medicinsk grundvetenskap

Annan medicinsk bioteknologi

DOI

10.3390/md17080469

PubMed

31409009

Mer information

Senast uppdaterat

2019-11-08