Controlled drug release under a low frequency magnetic field: effect of the citrate coating on magnetoliposomes stability
Artikel i vetenskaplig tidskrift, 2011

The paper describes the effect of a low-frequency alternating magnetic field (LF-AMF) on the permeability and release properties of large (LUVs) and giant (GUVs) unilamellar vesicles loaded with citrate coated cobalt ferrite nanoparticles (NPs). The citrate shell allows a high loading of NPs in lipid vesicles without modifying their magnetic properties. The increase of magnetic LUVs permeability upon exposure to LF-AMF has been evaluated as the fluorescence self-quenching of carboxyfluorescein (CF) entrapped inside the liposome aqueous pool. Liposome leakage has been monitored as a function of field frequency, time exposure and concentration of the citrate coated NPs. Confocal Laser Scanning Microscopy (CLSM) experiments performed on magnetic GUVs labeled with the fluorescent probe DiIC18 and loaded with Alexa 488-C5-maleimide fluorescent dye provided insights on the release mechanism induced by LF-AMF. The results show that LF-AMF strongly affects vesicles permeability, suggesting the formation of pores in the lipid bilayer due to both hyperthermic effects and nanoparticle oscillations in the vesicles pool at the applied frequency. The behaviour of these magnetic vesicles in the presence of LF-AMF makes this system a good candidate for controlled drug delivery.

surelease

cancer

modified superparamagnetic nanoparticles

glycol)

neutron-scattering

delivery systems

fluid

hpmc

liposomes

intracellular uptake

Författare

S. Nappini

CSGI

M. Bonini

CSGI

F. B. Bombelli

CSGI

F. Pineider

INSTM and Department of Chemistry U. Schiff

C. Sangregorio

Consiglio Nazionale delle Ricerche

P. Baglioni

CSGI

Bengt Nordén

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Soft Matter

1744-683X (ISSN) 1744-6848 (eISSN)

Vol. 7 3 1025-1037

Styrkeområden

Nanovetenskap och nanoteknik

Energi

Livsvetenskaper och teknik

Materialvetenskap

Ämneskategorier

Fysikalisk kemi

DOI

10.1039/c0sm00789g