Kinetic recognition of AT-rich DNA by ruthenium complexes
Artikel i vetenskaplig tidskrift, 2007
(Figure Presented) Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium (II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly-(dAdT) 2 than with mixed-sequence DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
TRIS(PHENANTHROLINE)RUTHENIUM(II)
STEREOSELECTIVITY
luminescence
SPECIFICITY
LIGANDS
MINOR-GROOVE
DISSOCIATION
SEQUENCE
kinetics
BINDING
DNA recognition
MODE
intercalation
THREADING INTERCALATION
ruthenium
Författare
Pär Nordell
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Fredrik Westerlund
Chalmers
Marcus Wilhelmsson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Bengt Nordén
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Per Lincoln
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 46 13 2203-2206Ämneskategorier
Fysikalisk kemi
DOI
10.1002/anie.200604294