Kinetic recognition of AT-rich DNA by ruthenium complexes
Artikel i vetenskaplig tidskrift, 2007

(Figure Presented) Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium (II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly-(dAdT) 2 than with mixed-sequence DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

TRIS(PHENANTHROLINE)RUTHENIUM(II)

intercalation

STEREOSELECTIVITY

luminescence

ruthenium

MINOR-GROOVE

LIGANDS

BINDING

THREADING INTERCALATION

MODE

SPECIFICITY

DISSOCIATION

SEQUENCE

kinetics

DNA recognition

Författare

Pär Nordell

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Fredrik Westerlund

Chalmers University of Technology

Marcus Wilhelmsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Bengt Nordén

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Per Lincoln

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 46 2203-2206

Ämneskategorier

Fysikalisk kemi

DOI

10.1002/anie.200604294