Kinetic recognition of AT-rich DNA by ruthenium complexes
Artikel i vetenskaplig tidskrift, 2007

(Figure Presented) Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium (II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly-(dAdT) 2 than with mixed-sequence DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

TRIS(PHENANTHROLINE)RUTHENIUM(II)

STEREOSELECTIVITY

luminescence

SPECIFICITY

LIGANDS

MINOR-GROOVE

DISSOCIATION

SEQUENCE

kinetics

BINDING

DNA recognition

MODE

intercalation

THREADING INTERCALATION

ruthenium

Författare

Pär Nordell

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Fredrik Westerlund

Chalmers

Marcus Wilhelmsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Bengt Nordén

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Per Lincoln

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 46 13 2203-2206

Ämneskategorier

Fysikalisk kemi

DOI

10.1002/anie.200604294