Fredrik Westerlund

2021

Optical dna mapping of plasmids reveals clonal spread of carbapenem-resistant klebsiella pneumoniae in a large thai hospital

2021

High prevalence of bla(CTX-M-15) and nosocomial transmission of hypervirulent epidemic clones of Klebsiella pneumoniae at a tertiary hospital in Ethiopia

Single Molecule Experiments Define the Role of Nbs1 and Xrs2 in DNA Tethering by MRN and MRX in DSB Repair

2021

The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA

2021

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis

Shining light on single-strand lesions caused by the chemotherapy drug bleomycin

2021

A parallelized nanofluidic device for high-throughput optical dna mapping of bacterial plasmids

2021

Complex conformational dynamics of the heart failure‐associated pre‐mirna‐377 hairpin revealed by single‐molecule optical tweezers

2021

Polyphasic characterization of carbapenemresistant Klebsiella pneumoniae clinical isolates suggests vertical transmission of the blaKPC-3gene

2021

Identity of blactx-m carrying plasmids in sequential esbl-e. Coli isolates from patients with recurrent urinary tract infections

2021

Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach

2021

Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents

2021

C-terminal truncation of α-synuclein alters DNA structure from extension to compaction

2021

Mechanical characterization of base analogue modified nucleic acids by force spectroscopy

2020

Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion

2020

Molecular Epidemiology of OXA-48 and NDM-1 Producing Enterobacterales Species at a University Hospital in Tehran, Iran, Between 2015 and 2016

2020

Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

2020

Optical maps of plasmids as a proxy for clonal spread of MDR bacteria: A case study of an outbreak in a rural Ethiopian hospital

Identifying Evolutionarily Conserved Features of NHEJ from Prokaryotes to Eukaryotes using Single-Molecule Approaches

DNA Bridging by the Homologous Recombination Component CtIP Investigated on the Single DNA Molecule Level

2020

Lipid vesicle composition influences the incorporation and fluorescence properties of the lipophilic sulphonated carbocyanine dye SP-DiO

Real-Time Condensation of Nanoconfined DNA by an Intrinsically Disordered Polycationic Protein

Studying the Intramolecular Forces of Base-Modified Nucleic Acids using Optical Tweezers

2020

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication

2020

Phosphorylated CtIP bridges DNA to promote annealing of broken ends

A Nanofluidic Device for Multiplexed Analysis of Single Exosomes

2020

Cultivation-Free Typing of Bacteria Using Optical DNA Mapping

Effect of Chirality on the Elastic Properties of the DNA-Threading Binuclear Ruthenium Complex

Multiplexed optical DNA mapping to identify plasmids and their resistance genes in fecal samples

2019

A nanofluidic device for parallel single nanoparticle catalysis in solution

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Genetic variation in the conjugative plasmidome of a hospital effluent multidrug resistant Escherichia coli strain

Optical DNA mapping using nanochannels for identification of plasmids carrying carbapenemase blandm-1 gene from patients admitted to a Vietnamese hospital

A nanofluidic device for real-time visualization of DNA–protein interactions on the single DNA molecule level

Bacterial identification by optical mapping of genomic DNA in nanofluidic channels

Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

Developing an optical DNA mapping toolbox to identify chromosomal translocations in acute myeloid leukemia

2019

Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels

High throughput size-determination and multiplexed fluorescence analysis of single biological particles in a nanofluidic device

Interspecies plasmid transfer appears rare in sequential infections with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae

2019

Enzyme-free optical DNA mapping of the human genome using competitive binding

A Nanofluidic Device for Real-Time Visualization of DNA-Protein Interactions on the Single DNA Molecule Level

Nanofluidic optical DNA mapping for rapid identification of antibiotics resistant plasmids

Reshaping the Energy Landscape Transforms the Mechanism and Binding Kinetics of DNA Threading Intercalation

Fluorescence microscopy of nanochannel-confined DNA

The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis

2018

Alpha-Synuclein Modulates the Physical Properties of DNA

2018

Bacterial response to graphene oxide and reduced graphene oxide integrated in agar plates

Stochastic unfolding of nanoconfined DNA: Experiments, model and Bayesian analysis

2018

Hairpins in the conformations of a confined polymer

Vertically Aligned Graphene Coating is Bactericidal and Prevents the Formation of Bacterial Biofilms

Interactions between DNA and HIV-1 Nucleocapsid Protein Studied using Nanofluidic Channels

PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction

2018

Facilitated sequence assembly using densely labeled optical DNA barcodes: A combinatorial auction approach

2018

Identification of pathogenic bacteria in complex samples using a smartphone based fluorescence microscope

2018

Identification and DNA annotation of a plasmid isolated from Chromobacterium violaceum

2017

Low Concentrations of Vitamin C Reduce the Synthesis of Extracellular Polymers and Destabilize Bacterial Biofilms

2017

Exploring DNA-protein interactions on the single DNA molecule level using nanofluidic tools

2017

A nano flow cytometer for single lipid vesicle analysis

2017

Noise reduction in single time frame optical DNA maps

Optical DNA mapping in nanofluidic devices: principles and applications

2017

Vitamin C Pretreatment Enhances the Antibacterial Effect of Cold Atmospheric Plasma

2017

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Binding of Thioflavin-T to Amyloid Fibrils Leads to Fluorescence Self-Quenching and Fibril Compaction

Efficient surface modification of carbon nanotubes for fabricating high performance CNT based hybrid nanostructures

Applications of optical DNA mapping in microbiology

Significance of Steric Bulk in DNA Threading Intercalation Revelaed through Force-Dependent Kinetics

2016

Single Particle Nanoplasmonic Sensing in Individual Nanofluidic Channels

2016

DNA intercalation optimized by two-step molecular lock mechanism

Rapid Tracing of Resistance Plasmids in a Nosocomial Outbreak Using Optical DNA Mapping

Visualizing the Nonhomogeneous Structure of RAD51 Filaments Using Nanofluidic Channels

Detailed characterization of plasmids carrying resistance genes using optical DNA mapping

2016

Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules

2016

DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels

2016

Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping.

Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation

Role of the Moiety Chirality in Determining the DNA Binding Characteristics of Threading Intercalators

Super-Resolution Genome Mapping in Silicon Nanochannels

Evidence for hydrophobic catalysis of DNA strand exchange

2015

Fast size-determination of intact bacterial plasmids using nanofluidic channels

Hydride formation thermodynamics and hysteresis in individual Pd nanocrystals with different size and shape

2015

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

Two-Step DNA Intercalation by Threading of the Flexible Ruthenium Dimer Studied by the Single Molecule DNA Stretching

Using nanofluidic channels to probe dynamics of RAD51-Filaments

Resolving the DNA Binding Mode of a Rotationally Flexible Binuclear Ruthenium Complex

2015

Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by A beta(1-40) and A beta(1-42)

Unfolding of nanoconfined circular DNA

Nanoconfined Circular and Linear DNA: Equilibrium Conformations and Unfolding Kinetics

Optical mapping of single DNA molecules in nanochannels: A novel method for identification and characterization of antibiotic resistance

2015

Extension of nanoconfined DNA: quantitative comparison between experiment and theory

2015

A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps

The Role of the Threading Moiety in DNA Threading Intercalation by Ruthenium Dimer Complexes

2015

Bacteriophage strain typing by rapid single molecule analysis

2014

Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex

2014

Competitive binding-based optical DNA mapping for fast identification of bacteria - multi-ligand transfer matrix theory and experimental applications on Escherichia coli

2014

Single-molecule electronics: from chemical design to functional devices

Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments

A Versatile Self-Assembly Strategy for the Synthesis of Shape-Selected Colloidal Noble Metal Nanoparticle Heterodimers

Nanoconfined circular DNA

Sensing Conformational Changes in DNA upon Ligand Binding Using QCM-D. Polyamine Condensation and Rad51 Extension of DNA Layers

Amyloid fibrils as dispersing agents for oligothiophenes: control of photophysical properties through nanoscale templating and flow induced fibril alignment

2014

The conquest of middle-earth: combining top-down and bottom-up nanofabrication for constructing nanoparticle based devices

Nanoconfined Circular DNA

Probing Physical Properties of a DNA- Protein Complex Using Nanofluidic Channels

Quantifying the DNA Binding Kinetics of a Ruthenium Dimer Complex with a Flexible Linker

Kinetics of DNA Threading Intercalation by a Rigid Ruthenium Complex Dimer

Self-Assembly and Near Perfect Macroscopic Alignment of Fluorescent Triangulenium Salt in Spin-Cast Thin Films on PTFE

Turn-On, Fluorescent Nuclear Stains with Live Cell Compatibility

Monomer distributions and intrachain collisions of a polymer confined to a channel

Identifying bacteria using DNA binding maps

Base Pair Sensitivity and Enhanced ON/OFF Ratios of DNA-Binding: Donor-Acceptor-Donor Fluorophores

Quantifying Force-Dependent Binding Kinetics of DNA-Ruthenium Complexes

Probing the Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels

What do photons do to fluorescently stained DNA in confinement?

Assessing How Cationic Intercalators Affect DNA using Nanofluidic Channels

Assessing how cationic intercalators affect DNA using nanofluidic channels

2013

Heterogeneous staining: a tool for studies of how fluorescent dyes affect the physical properties of DNA

Probing physical properties of DNA-protein complexes using nanofluidic channels

2012

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

2012

Lipid-Based Passivation in Nanofluidics

Large area, soft crystalline thin films of N,N ',N ''-trialkyltriazatriangulenium salts with homeotropic alignment of the discotic cores in a lamellar lattice

2012

Orientational correlations in confined DNA

A lipid-based passivation scheme for nanofluidics

A single-step competitive binding assay for mapping of single DNA molecules

Direct probing of ion pair formation using a symmetric triangulenium dye

Columnar Self-Assembly and Alignment of Planar Carbenium Ions in Langmuir-Blodgett Films

Interactions between a luminescent conjugated polyelectrolyte and amyloid fibrils investigated with flow linear dichroism spectroscopy

Fluorescence Enhancement of Single DNA Molecules Confined in Si/SiO2 Nanochannels

Fluorescence Enhancement From Single DNA Molecules Confined In Si/SiO2 Nanochannels

Local conformation of confined DNA studied using emission polarization anisotropy

Local conformation of confined DNA studied using emission polarization anisotropy

Trihydroxytrioxatriangulene—An Extended Fluorescein and a Ratiometric pH Sensor

Fluorescence enhancement from single DNA molecules confined in SiO 2 nanochannels

DNA strand exchange catalyzed by molecular crowding in PEG solutions

Mechanism of DNA Strand Exchange at Liposome Surfaces Investigated Using Mismatched DNA

Enhanced DNA strand exchange on positively charged liposomes

Mechanically manipulating the DNA threading intercalation rate

DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate

Finding at-DNA--kinetic recognition of long adenine-thymine stretches by metal-ligand complexes.

Complex DNA binding kinetics resolved-by combined circular dichroism and luminescence analysis

Kinetic characterization of an extremely slow DNA binding equilibrium

Kinetic recognition of AT-rich DNA by ruthenium complexes

Binding geometry and photophysical properties of DNA-threading binuclear ruthenium complexes

AT-dependent luminescence of DNA-threading ruthenium complexes

DNA Interaction Dynamics of Ruthenium(II) Complexes

Comparing mono- and divalent DNA groove binding cyanine dyes--Binding geometries, dissociation rates, and fluorescence properties

Enantioselective luminescence quenching of DNA light-switch [Ru(phen) 2dppz]2+ by electron transfer to structural homologue [Ru(phendione)2dppz]2+

Monitoring the DNA binding kinetics of a binuclear ruthenium complex by energy transfer: Evidence for slow shuffling

On semirigid binuclear ruthenium complexes and DNA : binding modes and kinetics

2003

Meso stereoisomer as a probe of enantioselective threading intercalation of semirigid ruthenium complex [µ-(11,11'-bidppz)(phen)4Ru2]4+

2003

Micelle-sequestered dissociation of cationic DNA-intercalated drugs: Unexpected surfactant-induced rate enhancement

2002

DNA-binding of semirigid binuclear ruthenium complex Δ,Δ-[µ-(11,11 '-bidppz)(phen)4Ru2]4+: Extremely slow intercalation kinetics