Fredrik Westerlund

2025

Biological Amyloids Chemically Damage DNA

2025

Stained DNA Dot Detection (SD³): An automated tool for quantifying fluorescent features along single stretched DNA molecules

2025

Force-induced melting and S-DNA pathways for DNA overstretching exhibit distinct kinetics

Binuclear ruthenium complex linker length tunes DNA threading intercalation kinetics

2025

Design and in vitro anticancer assessment of a click chemistry-derived dinuclear copper artificial metallo-nuclease

2025

High-throughput single molecule nanofluidic studies on B. subtilis Rok protein interaction with DNA

2024

Xrs2/NBS1 promote end-bridging activity of the MRE11-RAD50 complex

Thermodynamics and kinetics of the B-S transition in the wild-type and base-modified DNA

2024

Fluorescence Microscopy of Nanochannel-Confined DNA

Nanofluidics for analysing DNA-protein interactions on the single DNA molecule level

Nanofluidics highlights importance of CtIP's tetrameric structure for DNA repair

Sequence-Specific Minor Groove Binders in Labeling and Single-Molecule Analysis of DNA

2024

Photophysical image analysis: Unsupervised probabilistic thresholding for images from electron-multiplying charge-coupled devices

2024

Comparison of CTX-M encoding plasmids present during the early phase of the ESBL pandemic in western Sweden

2023

Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues

2023

Identification and characterization of plasmids carrying the mobile colistin resistance gene mcr-1 using optical DNA mapping

Probing physical properties of single amyloid fibrils using nanofluidic channels

Plasmonic polymer nanoantenna arrays for electrically tunable and electrode-free metasurfaces

Single molecule experiments highlight the role of NBS1 and Xrs2 in DNA tethering by MRN and MRX

2023

A Click Chemistry-Based Artificial Metallo-Nuclease

2023

Strain-level bacterial typing directly from patient samples using optical DNA mapping

A single-molecule view on non-homologous end-joining in bacteria

Short talk Studying the stability and conformational dynamics of the SARS-CoV-2 SL4 RNA hairpin combining base analogues and optical tweezers

Thermodynamics and kinetics of the B-S transition in base-modified DNA

2023

Polymer Brushes on Silica Nanostructures Prepared by Aminopropylsilatrane Click Chemistry: Superior Antifouling and Biofunctionality

2023

Probing physical properties of single amyloid fibrils using nanofluidic channels

2023

Label-Free Imaging of Catalytic H2O2 Decomposition on Single Colloidal Pt Nanoparticles Using Nanofluidic Scattering Microscopy

2022

High diversity of bla<inf>NDM-1</inf>-encoding plasmids in Klebsiella pneumoniae isolated from neonates in a Vietnamese hospital

2022

Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System

2022

Nanofluidic Trapping of Faceted Colloidal Nanocrystals for Parallel Single-Particle Catalysis

2022

Organic Anisotropic Excitonic Optical Nanoantennas

2022

HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells

2022

DNA in Nanochannels - Theory and Applications

2022

Fecal carriage and clonal dissemination of blaNDM-1 carrying Klebsiella pneumoniae sequence type 147 at an intensive care unit in Lao PDR

2022

Label-free nanofluidic scattering microscopy of size and mass of single diffusing molecules and nanoparticles

2022

Quantification of single-strand DNA lesions caused by the topoisomerase II poison etoposide using single DNA molecule imaging

2022

Polyclonal spread of bla<inf>CTX-M-15</inf> through high-risk clones of Escherichia coli at a tertiary hospital in Ethiopia

2022

A simple cut and stretch assay to detect antimicrobial resistance genes on bacterial plasmids by single-molecule fluorescence microscopy

2022

Left versus right: Exploring the effects of chiral threading intercalators using optical tweezers

Nanofluidics for single DNA molecule analysis of DNA repair

2021

Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach

2021

C-terminal truncation of α-synuclein alters DNA structure from extension to compaction

2021

Combining dense and sparse labeling in optical DNA mapping

2021

Optical dna mapping of plasmids reveals clonal spread of carbapenem-resistant klebsiella pneumoniae in a large thai hospital

2021

Complex conformational dynamics of the heart failure‐associated pre‐mirna‐377 hairpin revealed by single‐molecule optical tweezers

2021

High prevalence of bla(CTX-M-15) and nosocomial transmission of hypervirulent epidemic clones of Klebsiella pneumoniae at a tertiary hospital in Ethiopia

CRISPR/CAS9 BASED DNA-COMBING ASSAY FOR DETECTING ANTIMICROBIAL RESISTANCE GENES ON PLASMIDS

Single Molecule Experiments Define the Role of Nbs1 and Xrs2 in DNA Tethering by MRN and MRX in DSB Repair

2021

The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA

2021

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis

2021

Mechanical characterization of base analogue modified nucleic acids by force spectroscopy

2021

Polyphasic characterization of carbapenemresistant Klebsiella pneumoniae clinical isolates suggests vertical transmission of the bla<inf>KPC-3</inf>gene

2021

Identity of bla<inf>ctx-m</inf> carrying plasmids in sequential esbl-e. Coli isolates from patients with recurrent urinary tract infections

2021

Shining light on single-strand lesions caused by the chemotherapy drug bleomycin

2021

Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents

2021

A parallelized nanofluidic device for high-throughput optical dna mapping of bacterial plasmids

2020

Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion

Real-Time Condensation of Nanoconfined DNA by an Intrinsically Disordered Polycationic Protein

2020

Lipid vesicle composition influences the incorporation and fluorescence properties of the lipophilic sulphonated carbocyanine dye SP-DiO

2020

Molecular Epidemiology of OXA-48 and NDM-1 Producing Enterobacterales Species at a University Hospital in Tehran, Iran, Between 2015 and 2016

A Nanofluidic Device for Multiplexed Analysis of Single Exosomes

2020

Cultivation-Free Typing of Bacteria Using Optical DNA Mapping

Effect of Chirality on the Elastic Properties of the DNA-Threading Binuclear Ruthenium Complex

2020

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication

2020

Optical maps of plasmids as a proxy for clonal spread of MDR bacteria: A case study of an outbreak in a rural Ethiopian hospital

Identifying Evolutionarily Conserved Features of NHEJ from Prokaryotes to Eukaryotes using Single-Molecule Approaches

DNA Bridging by the Homologous Recombination Component CtIP Investigated on the Single DNA Molecule Level

2020

Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

Studying the Intramolecular Forces of Base-Modified Nucleic Acids using Optical Tweezers

2020

Phosphorylated CtIP bridges DNA to promote annealing of broken ends

Multiplexed optical DNA mapping to identify plasmids and their resistance genes in fecal samples

Genetic variation in the conjugative plasmidome of a hospital effluent multidrug resistant Escherichia coli strain

High throughput size-determination and multiplexed fluorescence analysis of single biological particles in a nanofluidic device

Developing an optical DNA mapping toolbox to identify chromosomal translocations in acute myeloid leukemia

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Optical DNA mapping using nanochannels for identification of plasmids carrying carbapenemase blandm-1 gene from patients admitted to a Vietnamese hospital

2019

Enzyme-free optical DNA mapping of the human genome using competitive binding

2019

A nanofluidic device for real-time visualization of DNA–protein interactions on the single DNA molecule level

2019

Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels

2019

A nanofluidic device for parallel single nanoparticle catalysis in solution

Bacterial identification by optical mapping of genomic DNA in nanofluidic channels

2019

Hydrophobic catalysis and a potential biological role of DNA unstacking induced by environment effects

2019

Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

Interspecies plasmid transfer appears rare in sequential infections with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae

2018

Alpha-Synuclein Modulates the Physical Properties of DNA

2018

Facilitated sequence assembly using densely labeled optical DNA barcodes: A combinatorial auction approach

2018

The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis

2018

Hairpins in the conformations of a confined polymer

PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction

A Nanofluidic Device for Real-Time Visualization of DNA-Protein Interactions on the Single DNA Molecule Level

Interactions between DNA and HIV-1 Nucleocapsid Protein Studied using Nanofluidic Channels

Nanofluidic optical DNA mapping for rapid identification of antibiotics resistant plasmids

2018

Bacterial response to graphene oxide and reduced graphene oxide integrated in agar plates

Reshaping the Energy Landscape Transforms the Mechanism and Binding Kinetics of DNA Threading Intercalation

Fluorescence microscopy of nanochannel-confined DNA

2018

Identification of pathogenic bacteria in complex samples using a smartphone based fluorescence microscope

Stochastic unfolding of nanoconfined DNA: Experiments, model and Bayesian analysis

2018

Identification and DNA annotation of a plasmid isolated from Chromobacterium violaceum

Vertically Aligned Graphene Coating is Bactericidal and Prevents the Formation of Bacterial Biofilms

Optical DNA mapping in nanofluidic devices: principles and applications

2017

Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms

Binding of Thioflavin-T to Amyloid Fibrils Leads to Fluorescence Self-Quenching and Fibril Compaction

2017

Exploring DNA-protein interactions on the single DNA molecule level using nanofluidic tools

2017

A nano flow cytometer for single lipid vesicle analysis

Efficient surface modification of carbon nanotubes for fabricating high performance CNT based hybrid nanostructures

2017

Low Concentrations of Vitamin C Reduce the Synthesis of Extracellular Polymers and Destabilize Bacterial Biofilms

2017

Vitamin C Pretreatment Enhances the Antibacterial Effect of Cold Atmospheric Plasma

2017

Noise reduction in single time frame optical DNA maps

2017

Applications of optical DNA mapping in microbiology

2016

Rapid Tracing of Resistance Plasmids in a Nosocomial Outbreak Using Optical DNA Mapping

2016

DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels

Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation

Role of the Moiety Chirality in Determining the DNA Binding Characteristics of Threading Intercalators

Significance of Steric Bulk in DNA Threading Intercalation Revelaed through Force-Dependent Kinetics

Visualizing the Nonhomogeneous Structure of RAD51 Filaments Using Nanofluidic Channels

2016

Single Particle Nanoplasmonic Sensing in Individual Nanofluidic Channels

2016

Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping.

Super-Resolution Genome Mapping in Silicon Nanochannels

Detailed characterization of plasmids carrying resistance genes using optical DNA mapping

2016

DNA intercalation optimized by two-step molecular lock mechanism

2016

Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules

2015

A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps

2015

Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by A beta(1-40) and A beta(1-42)

Nanoconfined Circular and Linear DNA: Equilibrium Conformations and Unfolding Kinetics

2015

Extension of nanoconfined DNA: quantitative comparison between experiment and theory

2015

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

Two-Step DNA Intercalation by Threading of the Flexible Ruthenium Dimer Studied by the Single Molecule DNA Stretching

Using nanofluidic channels to probe dynamics of RAD51-Filaments

Hydride formation thermodynamics and hysteresis in individual Pd nanocrystals with different size and shape

Resolving the DNA Binding Mode of a Rotationally Flexible Binuclear Ruthenium Complex

The Role of the Threading Moiety in DNA Threading Intercalation by Ruthenium Dimer Complexes

Unfolding of nanoconfined circular DNA

Optical mapping of single DNA molecules in nanochannels: A novel method for identification and characterization of antibiotic resistance

Evidence for hydrophobic catalysis of DNA strand exchange

2015

Bacteriophage strain typing by rapid single molecule analysis

2015

Fast size-determination of intact bacterial plasmids using nanofluidic channels

Amyloid fibrils as dispersing agents for oligothiophenes: control of photophysical properties through nanoscale templating and flow induced fibril alignment

2014

The conquest of middle-earth: combining top-down and bottom-up nanofabrication for constructing nanoparticle based devices

2014

A Versatile Self-Assembly Strategy for the Synthesis of Shape-Selected Colloidal Noble Metal Nanoparticle Heterodimers

2014

Single-molecule electronics: from chemical design to functional devices

Probing Physical Properties of a DNA- Protein Complex Using Nanofluidic Channels

Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments

2014

Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex

2014

Competitive binding-based optical DNA mapping for fast identification of bacteria - multi-ligand transfer matrix theory and experimental applications on Escherichia coli

Quantifying the DNA Binding Kinetics of a Ruthenium Dimer Complex with a Flexible Linker

Nanoconfined Circular DNA

Nanoconfined circular DNA

Kinetics of DNA Threading Intercalation by a Rigid Ruthenium Complex Dimer

Sensing Conformational Changes in DNA upon Ligand Binding Using QCM-D. Polyamine Condensation and Rad51 Extension of DNA Layers

Probing the Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels

Assessing How Cationic Intercalators Affect DNA using Nanofluidic Channels

Turn-On, Fluorescent Nuclear Stains with Live Cell Compatibility

2013

Heterogeneous staining: a tool for studies of how fluorescent dyes affect the physical properties of DNA

Base Pair Sensitivity and Enhanced ON/OFF Ratios of DNA-Binding: Donor-Acceptor-Donor Fluorophores

What do photons do to fluorescently stained DNA in confinement?

Self-Assembly and Near Perfect Macroscopic Alignment of Fluorescent Triangulenium Salt in Spin-Cast Thin Films on PTFE

Quantifying Force-Dependent Binding Kinetics of DNA-Ruthenium Complexes

Probing physical properties of DNA-protein complexes using nanofluidic channels

Monomer distributions and intrachain collisions of a polymer confined to a channel

Identifying bacteria using DNA binding maps

Assessing how cationic intercalators affect DNA using nanofluidic channels

Large area, soft crystalline thin films of N,N ',N ''-trialkyltriazatriangulenium salts with homeotropic alignment of the discotic cores in a lamellar lattice

A single-step competitive binding assay for mapping of single DNA molecules

2012

Orientational correlations in confined DNA

2012

Lipid-Based Passivation in Nanofluidics

A lipid-based passivation scheme for nanofluidics

2012

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

Interactions between a luminescent conjugated polyelectrolyte and amyloid fibrils investigated with flow linear dichroism spectroscopy

Direct probing of ion pair formation using a symmetric triangulenium dye

Columnar Self-Assembly and Alignment of Planar Carbenium Ions in Langmuir-Blodgett Films

Local conformation of confined DNA studied using emission polarization anisotropy

Local conformation of confined DNA studied using emission polarization anisotropy

DNA strand exchange catalyzed by molecular crowding in PEG solutions

Trihydroxytrioxatriangulene—An Extended Fluorescein and a Ratiometric pH Sensor

Fluorescence Enhancement of Single DNA Molecules Confined in Si/SiO2 Nanochannels

Fluorescence enhancement from single DNA molecules confined in SiO 2 nanochannels

Fluorescence Enhancement From Single DNA Molecules Confined In Si/SiO2 Nanochannels

Mechanism of DNA Strand Exchange at Liposome Surfaces Investigated Using Mismatched DNA

Complex DNA binding kinetics resolved-by combined circular dichroism and luminescence analysis

Enhanced DNA strand exchange on positively charged liposomes

DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate

Finding at-DNA--kinetic recognition of long adenine-thymine stretches by metal-ligand complexes.

Mechanically manipulating the DNA threading intercalation rate

Binding geometry and photophysical properties of DNA-threading binuclear ruthenium complexes

AT-dependent luminescence of DNA-threading ruthenium complexes

Kinetic characterization of an extremely slow DNA binding equilibrium

Kinetic recognition of AT-rich DNA by ruthenium complexes

DNA Interaction Dynamics of Ruthenium(II) Complexes

Comparing mono- and divalent DNA groove binding cyanine dyes--Binding geometries, dissociation rates, and fluorescence properties

Monitoring the DNA binding kinetics of a binuclear ruthenium complex by energy transfer: Evidence for slow shuffling

Enantioselective luminescence quenching of DNA light-switch [Ru(phen) 2dppz]2+ by electron transfer to structural homologue [Ru(phendione)2dppz]2+

On semirigid binuclear ruthenium complexes and DNA : binding modes and kinetics

2003

Meso stereoisomer as a probe of enantioselective threading intercalation of semirigid ruthenium complex [µ-(11,11'-bidppz)(phen)4Ru2]4+

2003

Micelle-sequestered dissociation of cationic DNA-intercalated drugs: Unexpected surfactant-induced rate enhancement

2002

DNA-binding of semirigid binuclear ruthenium complex Δ,Δ-[µ-(11,11 '-bidppz)(phen)4Ru2]4+: Extremely slow intercalation kinetics