Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms
Artikel i vetenskaplig tidskrift, 2017

Cold atmospheric plasma (CAP) is increasingly used in medical applications for eradication of bacterial and tumor
cells. CAP treatment devices, known as plasma jet pens, produce reactive oxygen and nitrogen species at
atmospheric pressure and room temperature. The produced reactive species are concentrated in a small and
precisely defined area, allowing for high precision medical treatments. CAP has been demonstrated as very effective
against planktonic bacterial cells. Unfortunately, bacterial cells in biofilms are typically aggregated and protected by
dense exopolymeric matrix, synthesized and secreted by the bacterial community. The main limitation in using CAP
against bacterial biofilms is the thick protective matrix of extracellular polymers that shields bacterial cells within this
complex architecture. CAP has also been shown to effectively eradicate tumor cells, but the main current limitation is
the susceptibility of the surrounding healthy tissues to higher doses. We have recently demonstrated that vitamin C,
a natural food supplement, can be used to destabilize bacterial biofilms and render them more susceptible to the
CAP killing treatment. Here we discuss the possible impact that a pre-treatment with vitamin C could have on CAP
applications in medicine. Specifically, we argue that vitamin C could enhance the effectiveness of CAP treatments
against both the bacterial biofilms and some selected tumors.

CAP

Bacterial bLofilms

Vitamin C

Författare

Santosh Pandit

Chalmers, Biologi och bioteknik, Systembiologi

Venkata Raghavendra Subrahmanya Sar Mokkapati

Oorganisk miljökemi 2

Saga Huld Helgadottir

Göteborgs universitet

Fredrik Westerlund

Chalmers, Biologi och bioteknik, Kemisk biologi

Ivan Mijakovic

Chalmers, Biologi och bioteknik, Systembiologi

Clinical microbiology

2327-5073 (ISSN)

Vol. 6 3 1-4 1000283

Ämneskategorier

Immunologi

Immunologi inom det medicinska området

Mikrobiologi

Styrkeområden

Livsvetenskaper och teknik (2010-2018)

DOI

10.4172/2327-5073.1000283

Mer information

Senast uppdaterat

2019-12-06