Combination of Cold Atmospheric Plasma and Vitamin C Effectively Disrupts Bacterial Biofilms
Journal article, 2017
cells. CAP treatment devices, known as plasma jet pens, produce reactive oxygen and nitrogen species at
atmospheric pressure and room temperature. The produced reactive species are concentrated in a small and
precisely defined area, allowing for high precision medical treatments. CAP has been demonstrated as very effective
against planktonic bacterial cells. Unfortunately, bacterial cells in biofilms are typically aggregated and protected by
dense exopolymeric matrix, synthesized and secreted by the bacterial community. The main limitation in using CAP
against bacterial biofilms is the thick protective matrix of extracellular polymers that shields bacterial cells within this
complex architecture. CAP has also been shown to effectively eradicate tumor cells, but the main current limitation is
the susceptibility of the surrounding healthy tissues to higher doses. We have recently demonstrated that vitamin C,
a natural food supplement, can be used to destabilize bacterial biofilms and render them more susceptible to the
CAP killing treatment. Here we discuss the possible impact that a pre-treatment with vitamin C could have on CAP
applications in medicine. Specifically, we argue that vitamin C could enhance the effectiveness of CAP treatments
against both the bacterial biofilms and some selected tumors.
Bacterial bLofilms
Vitamin C
CAP
Author
Santosh Pandit
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Venkata Raghavendra Subrahmanya Sar Mokkapati
Environmental Inorganic Chemistry 2
Saga Helgadottir
University of Gothenburg
Fredrik Westerlund
Chalmers, Biology and Biological Engineering, Chemical Biology
Ivan Mijakovic
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Technical University of Denmark (DTU)
Clinical microbiology
2327-5073 (ISSN)
Vol. 6 3 1000283Subject Categories
Immunology
Immunology in the medical area
Microbiology
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.4172/2327-5073.1000283