Vertically Aligned Graphene Coating is Bactericidal and Prevents the Formation of Bacterial Biofilms
Artikel i vetenskaplig tidskrift, 2018

The key first step in developing bacterial infections related to implants and medical devices is the attachment of planktonic bacterial cells, and subsequent formation of biofilms. Herein, it is reported that graphene, a 2D carbon-based material, can be effectively used to prevent bacterial attachment. The key parameter for this effect is the orientation of graphene with respect to the coated surface. Chemical vapor deposition (CVD) graphene, deposited horizontally on the surface, exhibits no antibacterial effect. By contrast, an array of graphene flakes grown perpendicularly to the surface by a plasma-enhanced CVD (PECVD) process prevent biofilm formation. Electron microscopy reveals that the exposed edges of vertically aligned graphene flakes penetrate the bacterial membrane and drain the cytosolic content. Bacteria are not able to develop resistance to this killing mechanism during multiple exposures. By keeping the height of the vertical graphene coating between 60 and 100 nm, the coating is able to effectively kill bacteria, while being completely harmless to mammalian cells.

mouse fibroblast cell

biofilm

antibacterial activity

vertical graphene

adhesion

Författare

Santosh Pandit

Chalmers, Biologi och bioteknik, Systembiologi

Z. Cao

Organisation okänd

Venkata Raghu Mokkapati

Chalmers, Biologi och bioteknik, Systembiologi

Emanuele Celauro

Chalmers, Biologi och bioteknik, Kemisk biologi

Avgust Yurgens

Chalmers, Mikroteknologi och nanovetenskap (MC2), Kvantkomponentfysik

Martin Lovmar

Wellspect Healthcare

Fredrik Westerlund

Chalmers, Biologi och bioteknik, Kemisk biologi

Jie Sun

Chalmers, Mikroteknologi och nanovetenskap (MC2), Kvantkomponentfysik

Beijing University of Technology

Wellspect Healthcare

Ivan Mijakovic

Chalmers, Biologi och bioteknik, Systembiologi

Advanced Materials Interfaces

2196-7350 (eISSN)

Vol. 5 7 1701331

Ämneskategorier

Bearbetnings-, yt- och fogningsteknik

Materialkemi

Medicinska material och protesteknik

DOI

10.1002/admi.201701331

Mer information

Senast uppdaterat

2018-05-25