Vertically Aligned Graphene Coating is Bactericidal and Prevents the Formation of Bacterial Biofilms
Artikel i vetenskaplig tidskrift, 2018
The key first step in developing bacterial infections related to implants and medical devices is the attachment of planktonic bacterial cells, and subsequent formation of biofilms. Herein, it is reported that graphene, a 2D carbon-based material, can be effectively used to prevent bacterial attachment. The key parameter for this effect is the orientation of graphene with respect to the coated surface. Chemical vapor deposition (CVD) graphene, deposited horizontally on the surface, exhibits no antibacterial effect. By contrast, an array of graphene flakes grown perpendicularly to the surface by a plasma-enhanced CVD (PECVD) process prevent biofilm formation. Electron microscopy reveals that the exposed edges of vertically aligned graphene flakes penetrate the bacterial membrane and drain the cytosolic content. Bacteria are not able to develop resistance to this killing mechanism during multiple exposures. By keeping the height of the vertical graphene coating between 60 and 100 nm, the coating is able to effectively kill bacteria, while being completely harmless to mammalian cells.
mouse fibroblast cell
adhesion
antibacterial activity
vertical graphene
biofilm
Författare
Santosh Pandit
Chalmers, Biologi och bioteknik, Systembiologi
Zhejian Cao
Chalmers, Mikroteknologi och nanovetenskap
Venkata Raghu Mokkapati
Chalmers, Biologi och bioteknik, Systembiologi
Emanuele Celauro
Chalmers, Biologi och bioteknik, Kemisk biologi
Avgust Yurgens
Chalmers, Mikroteknologi och nanovetenskap, Kvantkomponentfysik
Martin Lovmar
Wellspect Healthcare
Fredrik Westerlund
Chalmers, Biologi och bioteknik, Kemisk biologi
Jie Sun
Beijing University of Technology
Wellspect Healthcare
Chalmers, Mikroteknologi och nanovetenskap, Kvantkomponentfysik
Ivan Mijakovic
Chalmers, Biologi och bioteknik, Systembiologi
Advanced Materials Interfaces
2196-7350 (eISSN)
Vol. 5 7 1701331Styrkeområden
Nanovetenskap och nanoteknik
Ämneskategorier (SSIF 2011)
Bearbetnings-, yt- och fogningsteknik
Materialkemi
Annan fysik
Medicinska material och protesteknik
DOI
10.1002/admi.201701331