Marcus Wilhelmsson
Marcus Wilhelmssons grupp designar fluorescenta basanaloger för DNA och RNA. Forskningen syftar till att utveckla molekyler och metoder som underlättar för forskare som vill studera nukleinsyramolekylers struktur och dynamik samt dess interaktioner med proteiner och associerade konformationändringar. Med hjälp av dessa nya verktyg kan förståelsen för livsviktiga processer i celler som t.ex. replikation, transkription, genregulering, RNA-veckning och cellupptag av RNA-baserade terapier öka. Marcus Wilhelmsson är grundare till konferensen FB3 och till företaget LanteRNA. Mer info om Wilhelmssongruppen här.
Visar 88 publikationer
Synthesis and photophysical characterization of a pH-sensitive quadracyclic uridine (qU) analogue
Multiphoton characterization and live cell imaging using fluorescent adenine analogue 2CNqA
Thermodynamics and kinetics of the B-S transition in base-modified DNA
HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells
Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery
Mechanical characterization of base analogue modified nucleic acids by force spectroscopy
Interbase-FRET binding assay for pre-microRNAs
Development of functionalized SYBR green II related cyanine dyes for viral RNA detection
Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4
Studying the Intramolecular Forces of Base-Modified Nucleic Acids using Optical Tweezers
Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor
Interbase FRET in RNA: from A to Z
Fluorescence properties of 6-aryl-2 '-deoxy-furanouridine and pyrrolocytidine and their derivatives
Pentacyclic adenine: A versatile and exceptionally bright fluorescent DNA base analogue
FRET enhancement close to gold nanoparticles positioned in DNA origami constructs
Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET
Studying Z-DNA and B-to Z-DNA transitions using a cytosine analogue FRET-pair
Fluorescent Analogs of Biomolecular Building Blocks: Design and Applications
Chromophoric Nucleoside Analogues: Synthesis and Characterization of 6-Aminouracil-Based Nucleodyes
Synthesis and photophysical characterisation of new fluorescent triazole adenine analogues
The photoinduced transformation of fluorescent DNA base analogue tC triggers DNA melting
Controlling and Monitoring Orientation of DNA Nanoconstructs on Lipid Surfaces
FRETmatrix: a general methodology for the simulation and analysis of FRET in nucleic acids
Advances in Quantitative FRET-Based Methods for Studying Nucleic Acids
Mammalian transcription factor A is a core component of the mitochondrial transcription machinery
Quadracyclic Adenine: A Non-Perturbing Fluorescent Adenine Analogue
Discrimination against the Cytosine Analog tC by Escherichia coli DNA Polymerase IV DinB
Nanofabrication Yields. Hybridization and Click-Fixation of Polycyclic DNA Nanoassemblies
Fluorescent nucleic acid base analogues
A new fixation strategy for addressable nano-network building blocks
Characterization of Nucleobase Analogue FRET Acceptor tC(nitro)
Membrane-Anchored DNA Assembly for Energy and Electron Transfer
2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell imaging.
Highly efficient incorporation of the fluorescent nucleotide analogs tC and tC(O) by Klenow fragment
Thermodynamic Aspects of DNA Nanoconstruct Stability and Design
Stepwise Evolution of the Herpes Simplex Virus Origin Binding Protein and Origin of Replication
Nucleic acid structure and sequence probing using fluorescent base analogue tCo
Phospholipid membranes decorated by cholesterol-based oligonucleotides as soft hybrid nanostructures
Interactions of Antiviral Indolo[2,3-b]quinoxaline Derivatives with DNA
Addressable molecular node assembly - high information density DNA nanostructures
A membrane anchored DNA-based energy/electron transfer assembly
Characterization and use of tricyclic fluorescent nucleic acid base analogues
Addressable molecular node assembly--functional DNA nanostructures.
Addressable high-information-density DNA nanostructures
Conformational dynamics of DNA polymerase probed with a novel fluorescent DNA base analogue
Direct immobilization of cholesteryl-TEG-modified oligonucleotides onto hydrophobic SU-8 surfaces
Triplex addressability as a basis for functional DNA nanostructures
Kinetic recognition of AT-rich DNA by ruthenium complexes
Sequence-specific DNA Binding Agents
Photophysical Characterization of Fluorescent DNA Base Analogue, tC
Genetic screening using the colour change of a PNA-DNA hybrid-binding cyanine dye
A highly fluorescent DNA base analogue that forms Watson-Crick base pairs with guanine
Chromophores for visualisation of nucleic acid recognition processes
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Visar 7 forskningsprojekt
Endogennaturlik fluorescensmärkning villkor av RNA och dess användning i cellavbildning
Fluorescensbaserade studier av RNAs supertertiärstruktur och miRNA-interaktioner
Funktionell leverans av nukleotid-baserade läkemedel
Biosensing av miRNA och detektion av läkemedelsväxelverkan
A Novel Nucleic Base-base FRET method and its use in investigating transcription and replication