Fluorescence properties of 6-aryl-2 '-deoxy-furanouridine and pyrrolocytidine and their derivatives
Artikel i vetenskaplig tidskrift, 2018

2'-deoxyfuranouridine derivatives presenting various aryl groups have been synthesized through Cu(I)-catalyzed intramolecular cyclizations. Moreover, corresponding pyrrolo-dC derivatives have been synthesized and both families of compounds thoroughly characterized using UV/vis and fluorescence spectroscopy as well as time-dependent density functional theory calculations. The photophysical characterization, show that our newly synthesized derivatives of the important pyrrolo-dC family have high fluorescence quantum yields (QYs) and brightness values. Pyrrolo-dC derivative, 3a, shows an environment sensitive QY of up to >60% and brightness of almost 3000, in low polarity solvents and excitation and emission maxima between 365-381 nm and 479-510 nm, respectively, in solvents of different polarities. Two other derivatives, 3b and 3c, show high QYs and brightness values of up to 3300 that are fairly insensitive to their microenvironment. These promising photophysical features suggest future applicability as fluorescent nucleobase analogs.

base analog


nucleic acid



Jong Jin Ro

Pohang University of Science and Technology

Gui Han Go

Pohang University of Science and Technology

Byeang Hyean Kim

Pohang University of Science and Technology

Marcus Wilhelmsson

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Methods and Applications in Fluorescence

2050-6120 (eISSN)

Vol. 6 1 015004


Biokemi och molekylärbiologi


Teoretisk kemi



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