Marcus Wilhelmsson

Biträdande professor at Chemistry and Chemical Engineering, Chemistry and Biotechnology, Physical Chemistry

The Wilhelmsson group designs fluorescent base analogues for DNA and RNA as well as develops and utilizes methods using these probes to study biomolecular systems. The research aims at developing molecules and methods that facilitate investigations of structure and dynamics of nucleic acids as well as their interactions with proteins and associated conformational changes. Using this novel toolbox the understanding regarding vital cellular processes like e.g. replication, transcription, gene regulation and RNA folding will increase. Marcus Wilhelmsson is the founder of the conference FB3.Wilhelmsson research groupPublications - ResearcherID

Source: chalmers.se

Projects

2013–2014

A Novel Nucleic Base-base FRET method and its use in investigating transcription and replication

Marcus Wilhelmsson Physical Chemistry
Stiftelsen Olle Engkvist Byggmästare

2015–2017

Biosensing of miRNA and detection of its drug-interactions

Marcus Wilhelmsson Physical Chemistry
Swedish Foundation for Strategic Research (SSF)

2014–2017

Development and Utilization of FRET-probes - Revealing Novel Structure and Dynamics Information about Nucleic Acid Systems

Marcus Wilhelmsson Physical Chemistry
Swedish Research Council (VR)

There might be more projects where Marcus Wilhelmsson participates, but you have to be logged in as a Chalmers employee to see them.

Publications

2017

FRET enhancement close to gold nanoparticles positioned in DNA origami constructs

Nesrine Aissaoui, Kasper Moth-Poulsen, Mikael Käll et al
Nanoscale. Vol. 9 (2), p. 673-683
Scientific journal article - peer reviewed
2016

Studying Z-DNA and B-to Z-DNA transitions using a cytosine analogue FRET-pair

Blaise Dumat, Anders Foller Larsen, Marcus Wilhelmsson et al
Nucleic Acids Research. Vol. 44 (11)
Scientific journal article - peer reviewed
2016

Chromophoric Nucleoside Analogues: Synthesis and Characterization of 6-Aminouracil-Based Nucleodyes

N.S. Freeman, C.E. Moore, Marcus Wilhelmsson et al
Journal of Organic Chemistry. Vol. 81 (11), p. 4530-4539
Scientific journal article - peer reviewed
2016

Fluorescent Analogs of Biomolecular Building Blocks: Design and Applications

Marcus Wilhelmsson, Yitzhak Tor,
Monograph, book - edited
2016

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

M. Tokugawa, Y. Masaki, J. C. Canggadibrata et al
Chemical Communications. Vol. 52 (19), p. 3809-3812
Scientific journal article - peer reviewed
2015

Development of bright fluorescent quadracyclic adenine analogues: TDDFT-calculation supported rational design

Anders Foller Larsen, Blaise Dumat, Moa Sandberg Wranne et al
Scientific Reports. Vol. 5, p. art. no. 12653
Scientific journal article - peer reviewed
2015

Second-Generation Fluorescent Quadracyclic Adenine Analogues: Environment-Responsive Probes with Enhanced Brightness

B. Dumat, Mattias Bood, Moa Sandberg Wranne et al
Chemistry - A European Journal. Vol. 21 (10), p. 4039-4048
Scientific journal article - peer reviewed
2014

Synthesis and photophysical characterisation of new fluorescent triazole adenine analogues

Christopher P. Lawson, Anke Dierckx, Francois-Alexandre Miannay et al
Organic & Biomolecular Chemistry. Vol. 12 (28), p. 5158-5167
Scientific journal article - peer reviewed
2014

Antibody mediated fluorescence enhancement of nucleoside analogue 1,3-diaza-2-oxophenoxazine (tC degrees)

F. Sellrie, C. Lenz, A. Andersson et al
Talanta. Vol. 124, p. 67-70
Scientific journal article - peer reviewed
2014

The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation

Viktor Posse, Emily Hoberg, Anke Dierckx et al
Nucleic Acids Research. Vol. 42 (6), p. 3638-3647
Scientific journal article - peer reviewed
2013

The photoinduced transformation of fluorescent DNA base analogue tC triggers DNA melting

S. Preus, S. Jonck, M. Pittelkow et al
Photochemical & Photobiological Sciences. Vol. 12 (8), p. 1416-1422
Scientific journal article - peer reviewed
2013

DNA hosted and aligned in aqueous interstitia of a lamellar liquid crystal - a membrane-biomacromolecule interaction model system

Nils Carlsson, Fabian Jonsson, Marcus Wilhelmsson et al
Soft Matter. Vol. 9 (33), p. 7951-7959
Scientific journal article - peer reviewed
2013

Controlling and Monitoring Orientation of DNA Nanoconstructs on Lipid Surfaces

Erik Lundberg, Bobo Feng, Amir Saeid Mohammadi et al
Langmuir. Vol. 29 (1), p. 285-293
Scientific journal article - peer reviewed
2013

FRETmatrix: a general methodology for the simulation and analysis of FRET in nucleic acids

S. Preus, K. Kilsa, Francois-Alexandre Miannay et al
Nucleic Acids Research. Vol. 41 (1), p. Article Number: e18
Scientific journal article - peer reviewed
2012

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

Yonghong Shi, Anke Dierckx, Paulina Wanrooij et al
Proceedings of the National Academy of Science of the United States of America. Vol. 109 (41), p. 16510-16515
Scientific journal article - peer reviewed
2012

Advances in Quantitative FRET-Based Methods for Studying Nucleic Acids

S. Preus, Marcus Wilhelmsson,
Chembiochem. Vol. 13 (14), p. 1990-2001
Scientific journal article - peer reviewed
2012

Quadracyclic Adenine: A Non-Perturbing Fluorescent Adenine Analogue

Anke Dierckx, Francois-Alexandre Miannay, N. Gaied et al
Chemistry-a European Journal. Vol. 18 (19), p. 5987-5997
Scientific journal article - peer reviewed
2011

Nanofabrication Yields. Hybridization and Click-Fixation of Polycyclic DNA Nanoassemblies

Erik Lundberg, Calin Plesa, Marcus Wilhelmsson et al
ACS Nano. Vol. 5 (9), p. 7565-7575
Scientific journal article - peer reviewed
2011

Discrimination against the Cytosine Analog tC by Escherichia coli DNA Polymerase IV DinB

J. M. Walsh, I. Bouamaied, T. Brown et al
Journal of Molecular Biology. Vol. 409 (2), p. 89-100
Scientific journal article - peer reviewed
2011

Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA

Anke Dierckx, Peter Dinér, A. H. El-Sagheer et al
Nucleic Acids Research. Vol. 39 (10), p. 4513-4524
Scientific journal article - peer reviewed
2011

A Boost for the Emerging Field of RNA Nanotechnology - Report on the First International conference on RNA Nanotechnology

G. C. Shukla, F. Hague, Y. Tor et al
ACS Nano. Vol. 5 (5), p. 3405-3418
Scientific journal article - peer reviewed
2010

Fluorescent nucleic acid base analogues

Marcus Wilhelmsson,
Quarterly Reviews of Biophysics. Vol. 43 (2), p. 159-183
Scientific journal article - peer reviewed
2010

Photophysical and structural properties of the fluorescent nucleobase analogues of the tricyclic cytosine (tC) family

S. Preus, K. Kilsa, Marcus Wilhelmsson et al
Physical Chemistry Chemical Physics. Vol. 12 (31), p. 8881-8892
Scientific journal article - peer reviewed
2010

A new fixation strategy for addressable nano-network building blocks

Erik Lundberg, Afaf El-Sagheer, Petr Kocalka et al
Chemical Communications. Vol. 46 (21), p. 3714-3716
Scientific journal article - peer reviewed
2010

Characterization of Nucleobase Analogue FRET Acceptor tC(nitro)

S. Preus, Karl Börjesson, K. Kilså et al
Journal of Physical Chemistry B. Vol. 114 (2), p. 1050-1056
Scientific journal article - peer reviewed
2009

2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell imaging.

Christine Dyrager, Annika Friberg, Kristian Dahlén et al
Chemistry (Weinheim an der Bergstrasse, Germany). Vol. 15 (37), p. 9417-23
Scientific journal article - peer reviewed
2009

Ambivalent Incorporation of the Fluorescent Cytosine Analogues tC and tCo by Human DNA Polymerase alpha and Klenow Fragment

G. Stengel, B. W. Purse, Marcus Wilhelmsson et al
Biochemistry. Vol. 48 (31), p. 7547-7555
Scientific journal article - peer reviewed
2009

Highly efficient incorporation of the fluorescent nucleotide analogs tC and tC(O) by Klenow fragment

Peter Sandin, G. Stengel, Thomas Ljungdahl et al
Nucleic Acids Research. Vol. 37 (12), p. 3924-3933
Scientific journal article - peer reviewed
2009

Stepwise Evolution of the Herpes Simplex Virus Origin Binding Protein and Origin of Replication

Monica Olsson, Ka-Wei Tang, Cecilia Persson et al
Journal of Biological Chemistry. Vol. 284 (24), p. 16246-16255
Scientific journal article - peer reviewed
2009

Thermodynamic Aspects of DNA Nanoconstruct Stability and Design

Peter Sandin, John Tumpane, Karl Börjesson et al
Journal of Physical Chemistry C. Vol. 113 (15), p. 5941-5946
Scientific journal article - peer reviewed
2009

Membrane-Anchored DNA Assembly for Energy and Electron Transfer

Karl Börjesson, John Tumpane, Thomas Ljungdahl et al
Journal of the American Chemical Society. Vol. 131 (8), p. 2831-2839
Scientific journal article - peer reviewed
2009

Nucleic Acid Base Analog FRET-Pair Facilitating Detailed Structural Measurements in Nucleic Acid Containing Systems

Karl Börjesson, S. Preus, A. H. El-Sagheer et al
Journal of the American Chemical Society. Vol. 131 (12), p. 4288-4293
Scientific journal article - peer reviewed
2009

Synthesis and Photophysical Characterisation of Fluorescent 8-(1H-1,2,3-Triazol-4-yl)adenosine Derivatives

Christine Dyrager, Karl Börjesson, P. Diner et al
European Journal of Organic Chemistry (10), p. 1515-1521
Scientific journal article - peer reviewed
2009

Nucleic acid structure and sequence probing using fluorescent base analogue tCo

Karl Börjesson, Peter Sandin, Marcus Wilhelmsson et al
Biophysical Chemistry. Vol. 139 (1), p. 24-28
Scientific journal article - peer reviewed
2008

Interactions of Antiviral Indolo[2,3-b]quinoxaline Derivatives with DNA

Marcus Wilhelmsson, N. Kingi, J. Bergman et al
Journal of Medicinal Chemistry. Vol. 51 (24), p. 7744-7750
Scientific journal article - peer reviewed
2008

Phospholipid membranes decorated by cholesterol-based oligonucleotides as soft hybrid nanostructures

M. Banchelli, F. Betti, D. Berti et al
Journal of Physical Chemistry B. Vol. 112 (35), p. 10942-10952
Scientific journal article - peer reviewed
2008

Characterization and Use of an Unprecedentedly Bright and Structurally Non-Perturbing Fluorescent DNA Base Analogue

Peter Sandin, Karl Börjesson, Hong Li et al
Nucleic Acids Research. Vol. 36 (1), p. 157-167
Scientific journal article - peer reviewed
2007

Kinetic recognition of AT-rich DNA by ruthenium complexes

Pär Nordell, Fredrik Westerlund, Marcus Wilhelmsson et al
Angewandte Chemie-International Edition. Vol. 46 (13), p. 2203-2206
Scientific journal article - peer reviewed
2007

Triplex addressability as a basis for functional DNA nanostructures

John Tumpane, R. Kumar, Erik Lundberg et al
Nano Letters. Vol. 7 (12), p. 3832-3839
Scientific journal article - peer reviewed
2007

Conformational dynamics of DNA polymerase probed with a novel fluorescent DNA base analogue

G. Stengel, J. P. Gill, P. Sandin et al
Biochemistry. Vol. 46 (43), p. 12289-12297
Scientific journal article - peer reviewed
2007

Synthesis and Oligonucleotide Incorporation of Fluorescent Cytosine Analogue tC: a Promising Nucleic Acid Probe

Peter Sandin, Per Lincoln, Tom Brown et al
Nature Protocols. Vol. 2 (3), p. 615-623
Scientific journal article - peer reviewed
2007

Direct immobilization of cholesteryl-TEG-modified oligonucleotides onto hydrophobic SU-8 surfaces

Yavuz Erkan, Ilja Czolkos, Aldo Jesorka et al
Langmuir. Vol. 23 (10), p. 5259-5263
Scientific journal article - peer reviewed
2007

Addressable high-information-density DNA nanostructures

John Tumpane, Peter Sandin, R. Kumar et al
Chemical Physics Letters. Vol. 440 (1-3), p. 125-129
Scientific journal article - peer reviewed
2007

Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry

R. Kumar, A. El-Sagheer, John Tumpane et al
Journal of the American Chemical Society. Vol. 129 (21), p. 6859-6864
Scientific journal article - peer reviewed
2006

Sequence-specific DNA Binding Agents

Marcus Wilhelmsson, Per Lincoln, Bengt Nordén et al
Sequence-specific DNA Binding Agents
Chapter in monograph, book
2005

Monitoring the DNA binding kinetics of a binuclear ruthenium complex by energy transfer: Evidence for slow shuffling

Fredrik Westerlund, Marcus Wilhelmsson, Bengt Nordén et al
Journal of Physical Chemistry B. Vol. 109 (44), p. 21140-21144
Scientific journal article - peer reviewed
2005

Fluorescent Properties of DNA Base Analogue tC upon Incorporation into DNA - Negligible Influence of Neighboring Bases on Fluorescence Quantum Yield

Peter Sandin, Marcus Wilhelmsson, Per Lincoln et al
Nucleic Acid Research. Vol. 33 (16), p. 5019-5025
Scientific journal article - peer reviewed
2004

Effects of methyl substitution on radiative and solvent quenching rate constants of [Ru(phen)(2)dppz](2+) in polyol solvents and bound to DNA

Johan Olofsson, Marcus Wilhelmsson, Per Lincoln et al
Journal of the American Chemical Society. Vol. 126 (47), p. 15458-15465
Scientific journal article - peer reviewed
2004

DNA adopts normal B-form upon incorporation of highly fluorescent DNA base analogue tC: NMR structure and UV-Vis spectroscopy characterization

Cecilia Engman, Peter Sandin, Sadie Osborne et al
Nucleic Acids Research. Vol. 32 (17), p. 5087-95
Scientific journal article - peer reviewed
2003

Micelle-sequestered dissociation of cationic DNA-intercalated drugs: Unexpected surfactant-induced rate enhancement

Fredrik Westerlund, Marcus Wilhelmsson, Bengt Nordén et al
Journal of the American Chemical Society. Vol. 125 (13), p. 3773-3779
Scientific journal article - peer reviewed
2003

Meso stereoisomer as a probe of enantioselective threading intercalation of semirigid ruthenium complex [µ-(11,11'-bidppz)(phen)4Ru2]4+

Marcus Wilhelmsson, Elin Esbjörner, Fredrik Westerlund et al
Journal of Physical Chemistry B. Vol. 107 (42), p. 11784-11793
Scientific journal article - peer reviewed
2003

Photophysical Characterization of Fluorescent DNA Base Analogue, tC

Marcus Wilhelmsson, Peter Sandin, Anders Holmén et al
Journal of Physical Chemistry B. Vol. 107 (34), p. 9094-9101
Scientific journal article - peer reviewed
2003

Recognition and Visualization of Nucleic Acids

Marcus Wilhelmsson,
Doctoral thesis
2002

Genetic screening using the colour change of a PNA-DNA hybrid-binding cyanine dye

Marcus Wilhelmsson, Bengt Nordén, K. Mukherjee et al
Nucleic Acids Research. Vol. 30 (2)
Scientific journal article - peer reviewed
2002

DNA-binding of semirigid binuclear ruthenium complex Δ,Δ-[µ-(11,11 '-bidppz)(phen)4Ru2]4+: Extremely slow intercalation kinetics

Marcus Wilhelmsson, Fredrik Westerlund, Per Lincoln et al
Journal of the American Chemical Society. Vol. 124 (41), p. 12092-12093
Scientific journal article - peer reviewed
2001

A highly fluorescent DNA base analogue that forms Watson-Crick base pairs with guanine

Marcus Wilhelmsson, A. Holmen, Per Lincoln et al
Journal of the American Chemical Society. Vol. 123 (10), p. 2434-2435
Scientific journal article - peer reviewed