2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell imaging.
Journal article, 2009

We present the synthesis and photophysical characterisation of a series of structurally diverse, fluorescent 2,6,8-trisubstituted 3-hydroxychromone derivatives with high fluorescence quantum yields and molar extinction coefficients. Two of these derivatives (9 and 10 a) have been studied as fluorophores for cellular imaging in HeLa cells and show excellent permeability and promising fluorescence properties in a cellular environment. In addition, we have demonstrated by photophysical characterisation of 3-isobutyroxychromone derivatives that esterification of the 3-hydroxyl group results in acceptable and useful fluorescence properties.

Author

Christine Dyrager

University of Gothenburg

Annika Friberg

University of Gothenburg

Kristian Dahlén

University of Gothenburg

Maria Fridén-Saxin

University of Gothenburg

Karl Börjesson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Marcus Wilhelmsson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Maria Smedh

University of Gothenburg

Morten Grötli

University of Gothenburg

Kristina Luthman

University of Gothenburg

Chemistry - A European Journal

0947-6539 (ISSN) 1521-3765 (eISSN)

Vol. 15 37 9417-23

Subject Categories

Chemical Sciences

DOI

10.1002/chem.200900279

PubMed

19670192

More information

Latest update

4/18/2018