2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell imaging.
Artikel i vetenskaplig tidskrift, 2009

We present the synthesis and photophysical characterisation of a series of structurally diverse, fluorescent 2,6,8-trisubstituted 3-hydroxychromone derivatives with high fluorescence quantum yields and molar extinction coefficients. Two of these derivatives (9 and 10 a) have been studied as fluorophores for cellular imaging in HeLa cells and show excellent permeability and promising fluorescence properties in a cellular environment. In addition, we have demonstrated by photophysical characterisation of 3-isobutyroxychromone derivatives that esterification of the 3-hydroxyl group results in acceptable and useful fluorescence properties.


Christine Dyrager

Göteborgs universitet

Annika Friberg

Göteborgs universitet

Kristian Dahlén

Göteborgs universitet

Maria Fridén-Saxin

Göteborgs universitet

Karl Börjesson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Marcus Wilhelmsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Maria Smedh

Göteborgs universitet

Morten Grötli

Göteborgs universitet

Kristina Luthman

Göteborgs universitet

Chemistry - A European Journal

0947-6539 (ISSN) 1521-3765 (eISSN)

Vol. 15 37 9417-23