Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field
Artikel i vetenskaplig tidskrift, 2010

In this work we have studied the effect of a low-frequency alternating magnetic field (LF-AMF) on the permeability of magnetoliposomes, i.e. liposomes including magnetic nanoparticles within their water pool. Large unilamellar liposomes loaded with magnetic cobalt ferrite nanoparticles (CoFe 2O4) have been prepared and characterized. Structural characterization of the liposomal dispersion has been performed by dynamic light scattering (DLS). The enhancement of liposome permeability upon exposure to LF-AMF has been measured as the self-quenching decrease of a fluorescent hydrophilic molecule (carboxyfluorescein, CF) entrapped in the liposome pool. Liposome leakage has been monitored as a function of field frequency, time of exposure and concentration, charge and size of the embedded nanoparticles. The results show that CF release from magnetoliposomes is strongly promoted by LF-AMF, reasonably as a consequence of nanoparticle motions in the liposome pool at the applied frequency. CF release as a function of time in magnetoliposomes unexposed to magnetic field follows Fickian diffusion, while samples exposed to LF-AMF show zero-order kinetics, consistently with an anomalous transport, due to an alteration of the bilayer permeability. These preliminary results open up new perspectives in the use of these systems as carriers in targeted and controlled release of drugs.

Författare

Bengt Nordén

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

F. B. Bombelli

Universita degli Studi di Firenze

Francesca Baldelli Bombelli

Universita degli Studi di Firenze

Bengt Nordén

Chalmers

P. Baglioni

Universita degli Studi di Firenze

Soft Matter

1744-683X (ISSN) 1744-6848 (eISSN)

Vol. 6 1 154-162

Styrkeområden

Nanovetenskap och nanoteknik

Energi

Livsvetenskaper och teknik

Materialvetenskap

Ämneskategorier

Fysikalisk kemi

Fundament

Grundläggande vetenskaper

DOI

10.1039/b915651h

Mer information

Senast uppdaterat

2018-09-10