Enantiospecific kinking of DNA by a partially intercalating metal complex
Artikel i vetenskaplig tidskrift, 2012
Opposite enantiomers of [Ru(phenanthroline)(3)](2+) affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins.
specificity
crystal-structure
ruthenium complex
tris(phenanthroline)ruthenium(ii) enantiomers
dichroism
nucleic-acids
binding geometries
stereoselectivity
molecular-mechanics
linear
dynamics
Författare
Anna Reymer
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Bengt Nordén
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Chemical Communications
1359-7345 (ISSN) 1364-548X (eISSN)
Vol. 48 41 4941-4943Styrkeområden
Nanovetenskap och nanoteknik
Energi
Livsvetenskaper och teknik (2010-2018)
Materialvetenskap
Ämneskategorier
Kemi
DOI
10.1039/c2cc31176c