Enantiospecific kinking of DNA by a partially intercalating metal complex
Journal article, 2012
Opposite enantiomers of [Ru(phenanthroline)(3)](2+) affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins.
specificity
crystal-structure
ruthenium complex
tris(phenanthroline)ruthenium(ii) enantiomers
dichroism
nucleic-acids
binding geometries
stereoselectivity
molecular-mechanics
linear
dynamics
Author
Anna Reymer
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Bengt Nordén
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Chemical Communications
1359-7345 (ISSN) 1364-548X (eISSN)
Vol. 48 41 4941-4943Areas of Advance
Nanoscience and Nanotechnology
Energy
Life Science Engineering (2010-2018)
Materials Science
Subject Categories
Chemical Sciences
DOI
10.1039/c2cc31176c