Enantiospecific kinking of DNA by a partially intercalating metal complex
Journal article, 2012

Opposite enantiomers of [Ru(phenanthroline)(3)](2+) affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins.

specificity

crystal-structure

ruthenium complex

tris(phenanthroline)ruthenium(ii) enantiomers

dichroism

nucleic-acids

binding geometries

stereoselectivity

molecular-mechanics

linear

dynamics

Author

Anna Reymer

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Bengt Nordén

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Chemical Communications

1359-7345 (ISSN)

Vol. 48 41 4941-4943

Areas of Advance

Nanoscience and Nanotechnology (2010-2017)

Energy

Life Science Engineering (2010-2018)

Materials Science

Subject Categories

Chemical Sciences

DOI

10.1039/c2cc31176c

More information

Created

10/7/2017