Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice.
Journal article, 2011
The perinatal environment appears important in establishing metabolic phenotypes in adulthood. Mice deficient in IL-6 (IL-6(-/-)) tend to develop mature-onset obesity, but it is unknown whether perinatal exposure to IL-6 produced by the dam influences the metabolism of adult offspring. To address this issue, we monitored IL-6(-/-) offspring of IL-6(-/-) or IL-6(+/-) dams, as well as wild-type (WT) mice. At adult age, IL-6(-/-) mice weighed significantly more and had more body fat than WT mice, regardless of maternal genotype, and had lower insulin sensitivity. This phenotype was more pronounced in IL-6(-/-) offspring of IL-6(-/-) dams, because they gained weight significantly faster than IL-6(-/-) offspring of IL-6(+/-) dams and had more body fat and higher serum leptin levels at an earlier age. The leptin content was 2-fold higher in milk from IL-6(-/-) than WT dams. However, cross-fostering IL-6(-/-) mice with WT dams did not alter body weight, body composition, or adipocyte size at adult age compared with IL-6(-/-) mice fostered by IL-6(-/-) dams. Conversely, WT mice fostered by IL-6(-/-) dams weighed significantly more than those fostered by WT dams and had more body fat, larger adipocytes, and altered hypothalamic gene expression. We conclude that body fat of adult mice can be increased by perinatal exposure to factors affected by lack of maternal IL-6.
Body Composition
Milk
Female
Adiposity
deficiency
Hypothalamus
Mice
physiology
chemistry
Glucose Clamp Technique
Leptin
physiology
genetics
Male
RNA
physiology
Adipocytes
Messenger
Mutant Strains
Mice
Enzyme-Linked Immunosorbent Assay
cytology
metabolism
Pregnancy
Animals
metabolism
Body Weight
genetics
blood
genetics
genetics
physiology
Interleukin-6
Author
Susanne Lager
University of Gothenburg
Ingrid Wernstedt Asterholm
University of Gothenburg
Erik Schéle
University of Gothenburg
Nina Jansson
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
John-Olov Jansson
University of Gothenburg
Malin Lönn
University of Gothenburg
Agneta Holmäng
University of Gothenburg
Endocrinology
0013-7227 (ISSN)
Vol. 152 4 1336-46Subject Categories
Endocrinology and Diabetes
DOI
10.1210/en.2010-0921
PubMed
21285312