Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice.
Artikel i vetenskaplig tidskrift, 2011
The perinatal environment appears important in establishing metabolic phenotypes in adulthood. Mice deficient in IL-6 (IL-6(-/-)) tend to develop mature-onset obesity, but it is unknown whether perinatal exposure to IL-6 produced by the dam influences the metabolism of adult offspring. To address this issue, we monitored IL-6(-/-) offspring of IL-6(-/-) or IL-6(+/-) dams, as well as wild-type (WT) mice. At adult age, IL-6(-/-) mice weighed significantly more and had more body fat than WT mice, regardless of maternal genotype, and had lower insulin sensitivity. This phenotype was more pronounced in IL-6(-/-) offspring of IL-6(-/-) dams, because they gained weight significantly faster than IL-6(-/-) offspring of IL-6(+/-) dams and had more body fat and higher serum leptin levels at an earlier age. The leptin content was 2-fold higher in milk from IL-6(-/-) than WT dams. However, cross-fostering IL-6(-/-) mice with WT dams did not alter body weight, body composition, or adipocyte size at adult age compared with IL-6(-/-) mice fostered by IL-6(-/-) dams. Conversely, WT mice fostered by IL-6(-/-) dams weighed significantly more than those fostered by WT dams and had more body fat, larger adipocytes, and altered hypothalamic gene expression. We conclude that body fat of adult mice can be increased by perinatal exposure to factors affected by lack of maternal IL-6.
Body Composition
Milk
Female
Adiposity
deficiency
Hypothalamus
Mice
physiology
chemistry
Glucose Clamp Technique
Leptin
physiology
genetics
Male
RNA
physiology
Adipocytes
Messenger
Mutant Strains
Mice
Enzyme-Linked Immunosorbent Assay
cytology
metabolism
Pregnancy
Animals
metabolism
Body Weight
genetics
blood
genetics
genetics
physiology
Interleukin-6
Författare
Susanne Lager
Göteborgs universitet
Ingrid Wernstedt Asterholm
Göteborgs universitet
Erik Schéle
Göteborgs universitet
Nina Jansson
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Matematisk statistik
John-Olov Jansson
Göteborgs universitet
Malin Lönn
Göteborgs universitet
Agneta Holmäng
Göteborgs universitet
Endocrinology
0013-7227 (ISSN)
Vol. 152 4 1336-46Ämneskategorier
Endokrinologi och diabetes
DOI
10.1210/en.2010-0921
PubMed
21285312