Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice.
Artikel i vetenskaplig tidskrift, 2011

The perinatal environment appears important in establishing metabolic phenotypes in adulthood. Mice deficient in IL-6 (IL-6(-/-)) tend to develop mature-onset obesity, but it is unknown whether perinatal exposure to IL-6 produced by the dam influences the metabolism of adult offspring. To address this issue, we monitored IL-6(-/-) offspring of IL-6(-/-) or IL-6(+/-) dams, as well as wild-type (WT) mice. At adult age, IL-6(-/-) mice weighed significantly more and had more body fat than WT mice, regardless of maternal genotype, and had lower insulin sensitivity. This phenotype was more pronounced in IL-6(-/-) offspring of IL-6(-/-) dams, because they gained weight significantly faster than IL-6(-/-) offspring of IL-6(+/-) dams and had more body fat and higher serum leptin levels at an earlier age. The leptin content was 2-fold higher in milk from IL-6(-/-) than WT dams. However, cross-fostering IL-6(-/-) mice with WT dams did not alter body weight, body composition, or adipocyte size at adult age compared with IL-6(-/-) mice fostered by IL-6(-/-) dams. Conversely, WT mice fostered by IL-6(-/-) dams weighed significantly more than those fostered by WT dams and had more body fat, larger adipocytes, and altered hypothalamic gene expression. We conclude that body fat of adult mice can be increased by perinatal exposure to factors affected by lack of maternal IL-6.

Body Composition

Milk

Female

Adiposity

deficiency

Hypothalamus

Mice

physiology

chemistry

Glucose Clamp Technique

Leptin

physiology

genetics

Male

RNA

physiology

Adipocytes

Messenger

Mutant Strains

Mice

Enzyme-Linked Immunosorbent Assay

cytology

metabolism

Pregnancy

Animals

metabolism

Body Weight

genetics

blood

genetics

genetics

physiology

Interleukin-6

Författare

Susanne Lager

Göteborgs universitet

Ingrid Wernstedt Asterholm

Göteborgs universitet

Erik Schéle

Göteborgs universitet

Nina Jansson

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

John-Olov Jansson

Göteborgs universitet

Malin Lönn

Göteborgs universitet

Agneta Holmäng

Göteborgs universitet

Endocrinology

0013-7227 (ISSN)

Vol. 152 1336-46

Ämneskategorier

Endokrinologi och diabetes

DOI

10.1210/en.2010-0921

PubMed

21285312