Methylene blue intercalates with triplex poly(dT)*poly(dA)·poly(dT) but not duplex poly(dA)·poly(dT)
Journal article, 1995
Methylene blue intercalates with tripler poly(dT*dA.dT) even though it binds to the precursor duplex poly(dA.dT) in the major groove; the switch may be related to conformational modifications of the polynucleotide structure upon binding of the third strand.
spectroscopy
helix-specific ligands
antisense
ethidium-bromide
dna triplex
groove binding-drug
recognition
oligonucleotides
nucleic-acids
complex
Author
Eimer Tuite
Department of Physical Chemistry
Bengt Nordén
Department of Physical Chemistry
Journal of the Chemical Society - Series Chemical Communications
0022-4936 (ISSN)
1 53-54Subject Categories
Chemical Sciences
DOI
10.1039/c39950000053