The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome.
Journal article, 2011
High occurrence of measles, rubella and varicella zoster antibodies has been used as a biomarker for MS (the MRZ test). We analyzed measles antibody titres with respect to measles infection/measles vaccination status in 166 patients with MS or clinically isolated syndrome. Fifty blood donors served as controls. Measles vaccination yielded CSF measles antibodies in fewer patients (62%) than measles infection did (87%, p=0.001) and yielded lower measles titres in both serum and CSF (p<0.001). Controls had lower CSF measles titres than patients with measles vaccination alone (p<0.001). Childhood vaccinations probably reduce the sensitivity of the MRZ diagnostic test for MS.
Preschool
blood
blood
Adolescent
Child
Measles
cerebrospinal fluid
Vaccines
Female
blood
Adult
immunology
therapeutic use
Viral
Measles Vaccine
immunology
Multiple Sclerosis
Young Adult
Male
cerebrospinal fluid
immunology
Humans
cerebrospinal fluid
cerebrospinal fluid
therapeutic use
Attenuated
Middle Aged
Antibodies
immunology
Demyelinating Diseases
immunology
blood
Author
Cecilia Ahlgren
University of Gothenburg
Anders Odén
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Sara Haghighi
University of Gothenburg
Oluf Andersen
University of Gothenburg
Tomas Bergström
University of Gothenburg
Jan Lycke
University of Gothenburg
Journal of neuroimmunology
1872-8421 (eISSN)
Vol. 235 1-2 98-103Subject Categories
MEDICAL AND HEALTH SCIENCES
DOI
10.1016/j.jneuroim.2011.04.002
PubMed
21550125