The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome.
Artikel i vetenskaplig tidskrift, 2011

High occurrence of measles, rubella and varicella zoster antibodies has been used as a biomarker for MS (the MRZ test). We analyzed measles antibody titres with respect to measles infection/measles vaccination status in 166 patients with MS or clinically isolated syndrome. Fifty blood donors served as controls. Measles vaccination yielded CSF measles antibodies in fewer patients (62%) than measles infection did (87%, p=0.001) and yielded lower measles titres in both serum and CSF (p<0.001). Controls had lower CSF measles titres than patients with measles vaccination alone (p<0.001). Childhood vaccinations probably reduce the sensitivity of the MRZ diagnostic test for MS.

Preschool

blood

blood

Adolescent

Child

Measles

cerebrospinal fluid

Vaccines

Female

blood

Adult

immunology

therapeutic use

Viral

Measles Vaccine

immunology

Multiple Sclerosis

Young Adult

Male

cerebrospinal fluid

immunology

Humans

cerebrospinal fluid

cerebrospinal fluid

therapeutic use

Attenuated

Middle Aged

Antibodies

immunology

Demyelinating Diseases

immunology

blood

Författare

Cecilia Ahlgren

Göteborgs universitet

Anders Odén

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Sara Haghighi

Göteborgs universitet

Oluf Andersen

Göteborgs universitet

Tomas Bergström

Göteborgs universitet

Jan Lycke

Göteborgs universitet

Journal of neuroimmunology

1872-8421 (eISSN)

Vol. 235 1-2 98-103

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1016/j.jneuroim.2011.04.002

PubMed

21550125