The effect of hydroxyapatite nanocrystals on early bone formation surrounding dental implants.
Journal article, 2011
The knowledge of how nanostructures might affect early bone healing and osseointegration is limited. The aim of this study was to investigate if nanometer thick coatings of hydroxyapatite nanocrystals applied on a moderately rough surface might enhance early bone healing on screw-shaped dental implants and to evaluate if the thickness of the coat influences healing. Sandblasted and acid etched titanium implants coated with two different thicknesses of hydroxyapatite (test implants) and sandblasted and acid etched titanium implants (control implants), were inserted in rabbit tibia. After a healing time of 2, 4 and 9 weeks, a removal torque analysis and a histological evaluation were performed. The results from the removal torque analysis showed a tendency for higher values for the double coated hydroxyapatite after 4 weeks and for both the coated surfaces after 9 weeks of healing. The histological evaluations indicated slightly more new bone formation with the coated implants compared with the control; the differences did not reach statistical significance. The present study could not support the importance of nanometer thick coatings of hydroxyapatite nanocrystals in early bone healing, at least not when applied on a blasted and etched surface and placed in a cortical bone.
pathology
dental
surface topography
implants
in-vitro
chemistry
nanostructures
chemistry
Rabbits
Animal
Dental Materials
enhanced functions
Photoelectron Spectroscopy
Titanium
Models
chemistry
Torque
oral implants
Surface Properties
Dental Prosthesis Design
Osteogenesis
Electron
Durapatite
Nanoparticles
Dental Etching
hydroxyapatite coat
Dental Implants
Biocompatible
Time Factors
surgery
Materials Testing
physiology
calcium-phosphate
removal torque
Scanning
chemistry
Coated Materials
Acid Etching
osteoblast adhesion
chemistry
vivo
coatings
Osseointegration
Dental
Animals
Microscopy
physiology
acid-etched surface
Tibia
in vivo study
titanium implants
Author
Lory Melin Svanborg
University of Gothenburg
Maria Hoffman
University of Gothenburg
Martin Andersson
Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry
F Currie
Promimic AB
Per Kjellin
Promimic AB
Ann Wennerberg
University of Gothenburg
International journal of oral and maxillofacial surgery
1399-0020 (ISSN)
Vol. 40 3 308-15Subject Categories
Surgery
Dentistry
DOI
10.1016/j.ijom.2010.10.010
PubMed
21111575