The effect of hydroxyapatite nanocrystals on early bone formation surrounding dental implants.
Artikel i vetenskaplig tidskrift, 2011

The knowledge of how nanostructures might affect early bone healing and osseointegration is limited. The aim of this study was to investigate if nanometer thick coatings of hydroxyapatite nanocrystals applied on a moderately rough surface might enhance early bone healing on screw-shaped dental implants and to evaluate if the thickness of the coat influences healing. Sandblasted and acid etched titanium implants coated with two different thicknesses of hydroxyapatite (test implants) and sandblasted and acid etched titanium implants (control implants), were inserted in rabbit tibia. After a healing time of 2, 4 and 9 weeks, a removal torque analysis and a histological evaluation were performed. The results from the removal torque analysis showed a tendency for higher values for the double coated hydroxyapatite after 4 weeks and for both the coated surfaces after 9 weeks of healing. The histological evaluations indicated slightly more new bone formation with the coated implants compared with the control; the differences did not reach statistical significance. The present study could not support the importance of nanometer thick coatings of hydroxyapatite nanocrystals in early bone healing, at least not when applied on a blasted and etched surface and placed in a cortical bone.

in-vitro

Electron

Nanoparticles

Titanium

dental

Time Factors

Osteogenesis

Durapatite

Dental Implants

pathology

titanium implants

chemistry

Coated Materials

physiology

calcium-phosphate

nanostructures

acid-etched surface

Dental Etching

physiology

hydroxyapatite coat

Scanning

Materials Testing

Biocompatible

chemistry

oral implants

chemistry

coatings

implants

removal torque

Animal

enhanced functions

osteoblast adhesion

Dental

in vivo study

Photoelectron Spectroscopy

Surface Properties

Models

Dental Prosthesis Design

chemistry

Microscopy

surface topography

Acid Etching

vivo

Osseointegration

Torque

chemistry

Dental Materials

Tibia

Animals

Rabbits

surgery

Författare

Lory Melin Svanborg

Göteborgs universitet

Maria Hoffman

Göteborgs universitet

Martin Andersson

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

F Currie

Promimic AB

Per Kjellin

Promimic AB

Ann Wennerberg

Göteborgs universitet

International journal of oral and maxillofacial surgery

1399-0020 (ISSN)

Vol. 40 308-15

Ämneskategorier

Kirurgi

Odontologi

DOI

10.1016/j.ijom.2010.10.010

PubMed

21111575