Novel nanostructured microfibrillated cellulose–hydroxypropyl methylcellulose films with large one-dimensional swelling and tunable permeability
Journal article, 2012

Microfibrillated cellulose (MFC) films containing the water soluble and pharmaceutically approved polymer hydroxypropyl methylcellulose (HPMC) exhibited an unexpected decrease in permeability and excellent one-dimensional swelling properties above a threshold in HPMC content. It is proposed that the observed material characteristics derive from the influence of HPMC on the aggregation behavior of MFC in such a way that above a critical HPMC content the films are created through self assembly into a layered structure, composed of low swelling layers with swellable inter layer regions. The suggested structures were supported by high resolution microscopy. The findings should hold potential for direct applications, but even more as a concept for future material design.




Controlled release films




Mikael Larsson

Chalmers, Chemical and Biological Engineering, Pharmaceutical Technology

SuMo Biomaterials

Johan Hjärtstam

AstraZeneca AB

Anette Larsson

SuMo Biomaterials

Chalmers, Chemical and Biological Engineering, Pharmaceutical Technology

Carbohydrate Polymers

0144-8617 (ISSN)

2 763-771

Areas of Advance

Nanoscience and Nanotechnology (SO 2010-2017, EI 2018-)

Materials Science

Subject Categories

Materials Engineering

Physical Chemistry



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