Novel nanostructured microfibrillated cellulose–hydroxypropyl methylcellulose films with large one-dimensional swelling and tunable permeability
Artikel i vetenskaplig tidskrift, 2012

Microfibrillated cellulose (MFC) films containing the water soluble and pharmaceutically approved polymer hydroxypropyl methylcellulose (HPMC) exhibited an unexpected decrease in permeability and excellent one-dimensional swelling properties above a threshold in HPMC content. It is proposed that the observed material characteristics derive from the influence of HPMC on the aggregation behavior of MFC in such a way that above a critical HPMC content the films are created through self assembly into a layered structure, composed of low swelling layers with swellable inter layer regions. The suggested structures were supported by high resolution microscopy. The findings should hold potential for direct applications, but even more as a concept for future material design.

Permeability

Controlled release films

HPMC

Diffusion

Swelling

MFC

Författare

Mikael Larsson

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

SuMo Biomaterials

Johan Hjärtstam

AstraZeneca AB

Anette Larsson

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

SuMo Biomaterials

Carbohydrate Polymers

0144-8617 (ISSN)

763-771

Styrkeområden

Nanovetenskap och nanoteknik

Materialvetenskap

Ämneskategorier

Materialteknik

Fysikalisk kemi

DOI

10.1016/j.carbpol.2012.01.056