Kinetic model of HIV infection including hematopoietic progenitor cells
Journal article, 2012
Recent experiments indicate that one of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells. Such cells are nurtured in stem-cell niches residing in the bone marrow. Our generic four-variable kinetic model focused on this ingredient of HIV infection describes (i) a rapid increase of the population of infected CD4(+) T cells at the beginning of verimia, (ii) a sharp decline of this population due to immunological control, (iii) a long period of latency followed by a collapse of the immune system, and (iv) predicts that in the case of the therapy fully eradicating infected CD4(+) T cells the infection starts rapidly again after the therapy.
bone-marrow
dynamics
HIV kinetics
cellular-automata model
Hematopoietic progenitor cells
Immune-response cells
virus
viral replication
Mean-field kinetic equations
antiretroviral treatment
stem-cells
Antiretroviral therapy
Lymphocytes
intracellular delay
immune-response
t-cells
Author
Vladimir Zhdanov
Chalmers, Applied Physics, Chemical Physics
Mathematical Biosciences
0025-5564 (ISSN) 18793134 (eISSN)
Vol. 236 1 36-43Subject Categories
Condensed Matter Physics
DOI
10.1016/j.mbs.2012.01.003