Kinetic model of HIV infection including hematopoietic progenitor cells
Artikel i vetenskaplig tidskrift, 2012

Recent experiments indicate that one of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells. Such cells are nurtured in stem-cell niches residing in the bone marrow. Our generic four-variable kinetic model focused on this ingredient of HIV infection describes (i) a rapid increase of the population of infected CD4(+) T cells at the beginning of verimia, (ii) a sharp decline of this population due to immunological control, (iii) a long period of latency followed by a collapse of the immune system, and (iv) predicts that in the case of the therapy fully eradicating infected CD4(+) T cells the infection starts rapidly again after the therapy.

bone-marrow

dynamics

HIV kinetics

cellular-automata model

Hematopoietic progenitor cells

Immune-response cells

virus

viral replication

Mean-field kinetic equations

antiretroviral treatment

stem-cells

Antiretroviral therapy

Lymphocytes

intracellular delay

immune-response

t-cells

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Kemisk fysik

Mathematical Biosciences

0025-5564 (ISSN)

Vol. 236 1 36-43

Ämneskategorier

Den kondenserade materiens fysik

DOI

10.1016/j.mbs.2012.01.003