A combined tactile and Raman probe for tissue characterization - Design considerations
Journal article, 2012

Histopathology is the golden standard for cancer diagnosis and involves the characterization of tissue components. It is labour intensive and time consuming. We have earlier proposed a combined fibre-optic near-infrared Raman spectroscopy (NIR-RS) and tactile resonance method (TRM) probe for detecting positive surgical margins as a complement to interoperative histopathology. The aims of this study were to investigate the effects of attaching an RS probe inside a cylindrical TRM sensor and to investigate how laser-induced heating of the fibre-optic NIR-RS affected the temperature of the RS probe tip and an encasing TRM sensor. In addition, the possibility to perform fibre-optic NIR-RS in a well-lit environment was investigated. A small amount of rubber latex was preferable for attaching the thin RS probe inside the TRM sensor. The temperature rise of the TRM sensor due to a fibre-optic NIR-RS at 270 mW during 20 s was less than 2 degrees C. Fibre-optic NIR-RS was feasible in a dimmed bright environment using a small light shield and automatic subtraction of a pre-recorded contaminant spectrum. The results are promising for a combined probe for tissue characterization.


resonance sensor


optical-fiber probe







tactile sensor

Raman spectroscopy

biological tissue


M. Nyberg

Luleå University of Technology

Stefan Candefjord

Chalmers, Signals and Systems, Signalbehandling och medicinsk teknik, Biomedical Electromagnetics

V. Jalkanen

Luleå University of Technology

Umeå University

Kerstin Ramser

Luleå University of Technology

O. A. Lindahl

Luleå University of Technology

Umeå University

Measurement Science and Technology

0957-0233 (ISSN) 1361-6501 (eISSN)

Vol. 23 6 065901

Subject Categories

Analytical Chemistry

Condensed Matter Physics



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