A combined tactile and Raman probe for tissue characterization - Design considerations
Artikel i vetenskaplig tidskrift, 2012

Histopathology is the golden standard for cancer diagnosis and involves the characterization of tissue components. It is labour intensive and time consuming. We have earlier proposed a combined fibre-optic near-infrared Raman spectroscopy (NIR-RS) and tactile resonance method (TRM) probe for detecting positive surgical margins as a complement to interoperative histopathology. The aims of this study were to investigate the effects of attaching an RS probe inside a cylindrical TRM sensor and to investigate how laser-induced heating of the fibre-optic NIR-RS affected the temperature of the RS probe tip and an encasing TRM sensor. In addition, the possibility to perform fibre-optic NIR-RS in a well-lit environment was investigated. A small amount of rubber latex was preferable for attaching the thin RS probe inside the TRM sensor. The temperature rise of the TRM sensor due to a fibre-optic NIR-RS at 270 mW during 20 s was less than 2 degrees C. Fibre-optic NIR-RS was feasible in a dimmed bright environment using a small light shield and automatic subtraction of a pre-recorded contaminant spectrum. The results are promising for a combined probe for tissue characterization.


resonance sensor


optical-fiber probe







tactile sensor

Raman spectroscopy

biological tissue


M. Nyberg

Luleå tekniska universitet

Stefan Candefjord

Chalmers, Signaler och system, Signalbehandling och medicinsk teknik

V. Jalkanen

Luleå tekniska universitet

Umeå universitet

Kerstin Ramser

Luleå tekniska universitet

O. A. Lindahl

Luleå tekniska universitet

Umeå universitet

Measurement Science and Technology

0957-0233 (ISSN) 1361-6501 (eISSN)

Vol. 23 6 065901


Analytisk kemi

Den kondenserade materiens fysik



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