Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome
Journal article, 2012
In general, measles virus (MV) immunoglobulin G (IgG) antibody titres decline over time. However, we found that serum and CSF MV antibody titres increased with age (slope=0.038, p<0.001 and slope=0.022, p=0.008), respectively, and disease duration (slope=0.031, p=0.002 and slope=0.032, p=0.005), respectively, in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). The age dependency of serum antibody levels differed between patients and controls (slope=0.038 versus -0.004, p<0.001). The increasing MV antibody litres over time in MS/CIS patients support a general nonspecific stimulation of B cells and plasma cells that is not confined only to the CNS/CSF compartment.
inflammation
infection
b-cell follicles
matched controls
immune-response
Multiple sclerosis
cerebrospinal-fluid
Epidemiology
rubella
vaccine
CSF
epstein-barr-virus
Measles virus antibodies
rituximab
Author
Cecilia Ahlgren
Sahlgrenska University Hospital
Anders Odén
Chalmers, Mathematical Sciences, Mathematical Statistics
University of Gothenburg
Tomas Bergström
Sahlgrenska University Hospital
J. Lycke
Sahlgrenska University Hospital
Journal of Neuroimmunology
0165-5728 (ISSN) 18728421 (eISSN)
Vol. 247 1-2 70-74Subject Categories
Microbiology in the medical area
DOI
10.1016/j.jneuroim.2012.03.014