Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome
Artikel i vetenskaplig tidskrift, 2012

In general, measles virus (MV) immunoglobulin G (IgG) antibody titres decline over time. However, we found that serum and CSF MV antibody titres increased with age (slope=0.038, p<0.001 and slope=0.022, p=0.008), respectively, and disease duration (slope=0.031, p=0.002 and slope=0.032, p=0.005), respectively, in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). The age dependency of serum antibody levels differed between patients and controls (slope=0.038 versus -0.004, p<0.001). The increasing MV antibody litres over time in MS/CIS patients support a general nonspecific stimulation of B cells and plasma cells that is not confined only to the CNS/CSF compartment.

inflammation

infection

b-cell follicles

matched controls

immune-response

Multiple sclerosis

cerebrospinal-fluid

Epidemiology

rubella

vaccine

CSF

epstein-barr-virus

Measles virus antibodies

rituximab

Författare

Cecilia Ahlgren

Sahlgrenska universitetssjukhuset

Anders Odén

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Tomas Bergström

Sahlgrenska universitetssjukhuset

J. Lycke

Sahlgrenska universitetssjukhuset

Journal of Neuroimmunology

0165-5728 (ISSN)

Vol. 247 1-2 70-74

Ämneskategorier

Mikrobiologi inom det medicinska området

DOI

10.1016/j.jneuroim.2012.03.014

Mer information

Senast uppdaterat

2018-04-17