Orientational correlations in confined DNA
Journal article, 2012

We study how the orientational correlations of DNA confined to nanochannels depend on the channel diameter D by means of Monte Carlo simulations and a mean-field theory. This theory describes DNA conformations in the experimentally relevant regime where Flory-de Gennes theory does not apply. We show how local correlations determine the dependence of the end-to-end distance of the DNA molecule upon D. Tapered nanochannels provide the necessary resolution in D to study experimentally how the extension of confined DNA molecules depends upon D. Our experimental and theoretical results are in qualitative agreement.

Author

Erik Werner

University of Gothenburg

Fredrik Persson

University of Gothenburg

Fredrik Westerlund

Chalmers, Chemical and Biological Engineering, Physical Chemistry

J. O. Tegenfeldt

University of Gothenburg

Bernhard Mehlig

University of Gothenburg

Physical Review E

24700045 (ISSN) 24700053 (eISSN)

Vol. 86 4 041802-

Areas of Advance

Nanoscience and Nanotechnology (2010-2017)

Life Science Engineering (2010-2018)

Subject Categories

Physical Sciences

Biological Sciences

DOI

10.1103/PhysRevE.86.041802

More information

Created

10/7/2017