Complement Gene Single Nucleotide Polymorphisms and Biomarker Endophenotypes of Alzheimer's Disease
Journal article, 2013
The complement system has been implicated in both physiological synapse elimination and Alzheimer's disease (AD). Here, we investigated associations between four single nucleotide polymorphisms (SNPs) in complement genes and cerebrospinal fluid (CSF) biomarkers for AD in 452 neurochemically or neuropathologically verified AD cases and 678 cognitively normal controls. None of the SNPs associated with risk of AD but there were potential associations of rs9332739 in the C2 gene and rs4151667 in the complement factor B gene with CSF tau levels (p = 0.023) and Mini-Mental State Examination scores (p = 0.012), both of which may be considered markers of disease intensity/severity.
microglia
single nucleotide polymorphisms
Alzheimer's disease
complement
Author
Jonny Daborg
University of Gothenburg
Sandra Holmgren
University of Gothenburg
Alexandra Abramsson
University of Gothenburg
Ulf Andreasson
University of Gothenburg
Madeleine Zetterberg
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
L. Minthon
Lund University
Ingmar Skoog
University of Gothenburg
Kaj Blennow
University of Gothenburg
Marcela Pekna
University of Gothenburg
Eric Hanse
University of Gothenburg
Henrik Zetterberg
University of Gothenburg
Journal of Alzheimers Disease
1387-2877 (ISSN)
Vol. 35 1 51-57Subject Categories
Neurosciences
Other Medical and Health Sciences
DOI
10.3233/JAD-121930
PubMed
23313922