Complement Gene Single Nucleotide Polymorphisms and Biomarker Endophenotypes of Alzheimer's Disease
Artikel i vetenskaplig tidskrift, 2013
The complement system has been implicated in both physiological synapse elimination and Alzheimer's disease (AD). Here, we investigated associations between four single nucleotide polymorphisms (SNPs) in complement genes and cerebrospinal fluid (CSF) biomarkers for AD in 452 neurochemically or neuropathologically verified AD cases and 678 cognitively normal controls. None of the SNPs associated with risk of AD but there were potential associations of rs9332739 in the C2 gene and rs4151667 in the complement factor B gene with CSF tau levels (p = 0.023) and Mini-Mental State Examination scores (p = 0.012), both of which may be considered markers of disease intensity/severity.
microglia
single nucleotide polymorphisms
Alzheimer's disease
complement
Författare
Jonny Daborg
Göteborgs universitet
Sandra Holmgren
Göteborgs universitet
Alexandra Abramsson
Göteborgs universitet
Ulf Andreasson
Göteborgs universitet
Madeleine Zetterberg
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Matematisk statistik
L. Minthon
Lunds universitet
Ingmar Skoog
Göteborgs universitet
Kaj Blennow
Göteborgs universitet
Marcela Pekna
Göteborgs universitet
Eric Hanse
Göteborgs universitet
Henrik Zetterberg
Göteborgs universitet
Journal of Alzheimers Disease
1387-2877 (ISSN)
Vol. 35 1 51-57Ämneskategorier
Neurovetenskaper
Annan medicin och hälsovetenskap
DOI
10.3233/JAD-121930
PubMed
23313922