Complement Gene Single Nucleotide Polymorphisms and Biomarker Endophenotypes of Alzheimer's Disease
Artikel i vetenskaplig tidskrift, 2013

The complement system has been implicated in both physiological synapse elimination and Alzheimer's disease (AD). Here, we investigated associations between four single nucleotide polymorphisms (SNPs) in complement genes and cerebrospinal fluid (CSF) biomarkers for AD in 452 neurochemically or neuropathologically verified AD cases and 678 cognitively normal controls. None of the SNPs associated with risk of AD but there were potential associations of rs9332739 in the C2 gene and rs4151667 in the complement factor B gene with CSF tau levels (p = 0.023) and Mini-Mental State Examination scores (p = 0.012), both of which may be considered markers of disease intensity/severity.

microglia

single nucleotide polymorphisms

Alzheimer's disease

complement

Författare

Jonny Daborg

Göteborgs universitet

Sandra Holmgren

Göteborgs universitet

Alexandra Abramsson

Göteborgs universitet

Ulf Andreasson

Göteborgs universitet

Madeleine Zetterberg

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

L. Minthon

Lunds universitet

Ingmar Skoog

Göteborgs universitet

Kaj Blennow

Göteborgs universitet

Marcela Pekna

Göteborgs universitet

Eric Hanse

Göteborgs universitet

Henrik Zetterberg

Göteborgs universitet

Journal of Alzheimers Disease

1387-2877 (ISSN)

Vol. 35 1 51-57

Ämneskategorier

Neurovetenskaper

Annan medicin och hälsovetenskap

DOI

10.3233/JAD-121930

PubMed

23313922