Chemical Analysis of Single Cells
Review article, 2013

In this Review, we provide an overview of methods developed for chemical analysis of single cells over the last two years. Many biological systems contain an ensemble of cells with heterogeneous chemistry; therefore, it is important to analyze them on an individual basis in order to elucidate the role each cell plays in the function of these systems. In clinical diagnostics, the development of extremely sensitive measurements, down to single cells, may provide the best ability for diagnoses. Single cell analysis has, in fact, been present for quite some time. Investigators in life sciences consider the cell as the unit of life and so the pursuit to quantify, image, and modulate the cell has been ongoing for decades.

ion mass-spectrometry

living cells

fluorescent protein




multifunctional pipette

neuroendocrine cells

sample preparation

scanning electrochemical microscopy

droplet microfluidics


R. Trouillon

University of Gothenburg

Melissa Passarelli

University of Gothenburg

J. Wang

University of Gothenburg

Michael Kurczy

Chalmers, Chemical and Biological Engineering, Analytical Chemistry

Andrew Ewing

Chalmers, Chemical and Biological Engineering, Analytical Chemistry

Analytical Chemistry

0003-2700 (ISSN) 1520-6882 (eISSN)

Vol. 85 2 522-542

Subject Categories

Analytical Chemistry



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