Chemical Analysis of Single Cells
Reviewartikel, 2013
In this Review, we provide an overview of methods developed
for chemical analysis of single cells over the last two years.
Many biological systems contain an ensemble of cells with
heterogeneous chemistry; therefore, it is important to analyze
them on an individual basis in order to elucidate the role each cell
plays in the function of these systems. In clinical diagnostics, the
development of extremely sensitive measurements, down to
single cells, may provide the best ability for diagnoses. Single cell
analysis has, in fact, been present for quite some time.
Investigators in life sciences consider the cell as the unit of life
and so the pursuit to quantify, image, and modulate the cell has
been ongoing for decades.
ion mass-spectrometry
living cells
fluorescent protein
oxygen
reactive
in-vivo
multifunctional pipette
neuroendocrine cells
sample preparation
scanning electrochemical microscopy
droplet microfluidics
Författare
R. Trouillon
Göteborgs universitet
Melissa Passarelli
Göteborgs universitet
J. Wang
Göteborgs universitet
Michael Kurczy
Chalmers, Kemi- och bioteknik, Analytisk kemi
Andrew Ewing
Chalmers, Kemi- och bioteknik, Analytisk kemi
Analytical Chemistry
0003-2700 (ISSN) 1520-6882 (eISSN)
Vol. 85 2 522-542Ämneskategorier
Analytisk kemi
DOI
10.1021/ac303290s