Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?
Journal article, 2012
The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. To further elucidate the possible relevance of inflammation for mental functions, we investigated a functional polymorphism in the gene coding for RAGE in relation to personality traits and susceptibility to schizophrenia.
Male
Schizophrenia
Single Nucleotide
psychology
S100 Proteins
Polymorphism
genetics
Personality Tests
Middle Aged
Genotype
Female
Immunologic
Case-Control Studies
Humans
genetics
Schizophrenic Psychology
Receptors
Psychotic Disorders
Genetic
genetics
genetics
Personality
genetics
genetics
Polymorphism
DNA
Cohort Studies
Nerve Growth Factors
Author
Petra Suchankova
University of Gothenburg
Jonas Klang
University of Gothenburg
Carin Cavanna
University of Gothenburg
Göran Holm
University of Gothenburg
Staffan Nilsson
Chalmers, Mathematical Sciences, Mathematical Statistics
University of Gothenburg
Erik G Jönsson
Karolinska University Hospital
Agneta Ekman
University of Gothenburg
Journal of Psychiatry and Neuroscience
1180-4882 (ISSN) 1488-2434 (eISSN)
Vol. 37 2 122-128Subject Categories
Pharmacology and Toxicology
DOI
10.1503/jpn.110024
PubMed
22146151