Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?
Artikel i vetenskaplig tidskrift, 2012
The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. To further elucidate the possible relevance of inflammation for mental functions, we investigated a functional polymorphism in the gene coding for RAGE in relation to personality traits and susceptibility to schizophrenia.
Male
Schizophrenia
Single Nucleotide
psychology
S100 Proteins
Polymorphism
genetics
Personality Tests
Middle Aged
Genotype
Female
Immunologic
Case-Control Studies
Humans
genetics
Schizophrenic Psychology
Receptors
Psychotic Disorders
Genetic
genetics
genetics
Personality
genetics
genetics
Polymorphism
DNA
Cohort Studies
Nerve Growth Factors
Författare
Petra Suchankova
Göteborgs universitet
Jonas Klang
Göteborgs universitet
Carin Cavanna
Göteborgs universitet
Göran Holm
Göteborgs universitet
Staffan Nilsson
Chalmers, Matematiska vetenskaper, Matematisk statistik
Göteborgs universitet
Erik G Jönsson
Karolinska universitetssjukhuset
Agneta Ekman
Göteborgs universitet
Journal of Psychiatry and Neuroscience
1180-4882 (ISSN) 1488-2434 (eISSN)
Vol. 37 2 122-128Ämneskategorier
Farmakologi och toxikologi
DOI
10.1503/jpn.110024
PubMed
22146151