Effect of age on amount and distribution of diffuse axonal injury after rotational trauma
Conference contribution, 2013

Injury thresholds for diffuse axonal injuries (DAI) due to rotational head trauma are being developed. However, age may influence injury risk. Understanding this relationship is necessary for the development of injury criteria for children and elderly. Here rats were exposed to sagittal plane rotational acceleration head trauma and the outcome studied using Amyloid Precursor Protein to detect axonal injuries. For relatively young animals, DAI were found in and along the border of the corpus callosum and in the brainstem when rotational acceleration exceeded 1.1 Mrad/s2. Slightly older animals required higher accelerations to exhibit similar injury levels and the injury patterns were different. In conclusion, a previous study showed that the onset of diffuse axonal injuries started to appear at 10 krad/s2 with a duration of 4 ms, when scaled for humans, whereas new data indicate that this onset is slightly higher for occupants thata atre approximately 15 years older.

Age

Brain

Diffuse Axonal Injury

Safety

Author

Johan Davidsson

SAFER, The Vehicle and Traffic Safety Centre

Chalmers, Applied Mechanics, Vehicle Safety

Maria Angeria

Mårten Risling

Proceeding of JSAE Annual Congress, Yokohama, Japan

20135479

Subject Categories

Mechanical Engineering

Areas of Advance

Transport

More information

Created

10/7/2017