Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity
Journal article, 2014
The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH(3)) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L-1)](ttcH(2))(ClO4)center dot EtOH center dot H2O (1), where L-1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
complexes
trimercaptotriazine
crystal structure
Schiff base
trithiocyanuric acid
acetylcholinesterase activity
Author
Pavel Kopel
Brno University of Technology
Mendelova univerzita v Brne
Karel Dolezal
Palacky University Olomouc
Vratislav Langer
Chalmers, Chemical and Biological Engineering, Environmental Inorganic Chemistry
D. Jun
University Hospital Hradec Kralove
Univerzita obrany v Brne
V. Adam
Mendelova univerzita v Brne
Brno University of Technology
K. Kuca
University Hospital Hradec Kralove
R. Kizek
Mendelova univerzita v Brne
Brno University of Technology
Molecules
1420-3049 (ISSN) 14203049 (eISSN)
Vol. 19 4 4338-4354Subject Categories
Inorganic Chemistry
DOI
10.3390/molecules19044338