Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity
Journal article, 2014

The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH(3)) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L-1)](ttcH(2))(ClO4)center dot EtOH center dot H2O (1), where L-1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.

crystal structure

acetylcholinesterase activity

complexes

trimercaptotriazine

trithiocyanuric acid

Schiff base

Author

Pavel Kopel

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

Mendelova univerzita v Brne

Karel Dolezal

Palacky University Olomouc

Vratislav Langer

Chalmers, Chemical and Biological Engineering, Environmental Inorganic Chemistry

D. Jun

Faculty Hospital at Hradec Kralove

Univerzita obrany v Brne

V. Adam

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

Mendelova univerzita v Brne

K. Kuca

Faculty Hospital at Hradec Kralove

R. Kizek

Mendelova univerzita v Brne

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

Molecules

1420-3049 (ISSN)

Vol. 19 4 4338-4354

Subject Categories

Inorganic Chemistry

DOI

10.3390/molecules19044338

More information

Created

10/7/2017