Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies
Review article, 2014
Development of therapeutics for brain disorders is one of the more difficult challenges to be overcome by the scientific community due to the inability of most molecules to cross the blood-brain barrier (BBB). Antibody-conjugated nanoparticles are drug carriers that can be used to target encapsulated drugs to the brain endothelial cells and have proven to be very promising. They significantly improve the accumulation of the drug in pathological sites and decrease the undesirable side effect of drugs in healthy tissues. We review the systems that have demonstrated promising results in crossing the BBB through receptor-mediated endocytic mechanisms for the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
enable drug-delivery
alzheimers-disease
in-vivo
sterically stabilized liposomes
central-nervous-system
amyloid-beta peptide
rat-brain
antitransferrin receptor antibody
transferrin-receptor
gene-therapy
Author
J. A. Loureiro
University of Porto
Bárbara Gomes
University of Porto
M. A. N. Coelho
University of Porto
M. C. Pereira
University of Porto
Sandra Rocha
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Nanomedicine
1743-5889 (ISSN) 1748-6963 (eISSN)
Vol. 9 5 709-722Subject Categories
Biological Sciences
DOI
10.2217/NNM.14.27