Sandra Rocha

Researcher at Chemical Biology

Contact Details ORCID

Publications (36)
Projects (2)

Showing 36 publications

2021

C-terminal truncation of α-synuclein alters DNA structure from extension to compaction

Kai Jiang, Sandra Rocha, Ranjeet Kumar et al

Biochemical and Biophysical Research Communications. Vol. 568, p. 43-47

Journal article

2021

Orientation of α-Synuclein at Negatively Charged Lipid Vesicles: Linear Dichroism Reveals Time-Dependent Changes in Helix Binding Mode

Sandra Rocha, Ranjeet Kumar, Bengt Nordén et al

Journal of the American Chemical Society. Vol. 143 (45), p. 18899-18906

Journal article

2020

Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein

Jonas Hannestad, Sandra Rocha, Björn Agnarsson et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (25), p. 14178-14186

Journal article

2020

Michler's hydrol blue elucidates structural differences in prion strains

Yiling Xiao, Sandra Rocha, Catherine Kitts et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (47), p. 29677-29683

Journal article

2020

Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers

Tony Werner, David Bernson, Elin Esbjörner Winters et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 117 (45), p. 27997-28004

Journal article

2019

Membrane-Protein-Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

Jan Dedic, Sandra Rocha, Halil I. Okur et al

Journal of Physical Chemistry B. Vol. 123 (5), p. 1044-1049

Journal article

2019

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Kai Jiang, Sandra Rocha, Alvina Westling et al

Biophysical Journal

Paper in proceeding

2019

Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity

Sandra Rocha, Ranjeet Kumar, Istvan Horvath et al

Protein engineering, design & selection : PEDS. Vol. 32 (2), p. 59-66

Journal article

2019

Membrane-protein-hydration interaction of alpha-synuclein with anionic vesicles in solution probed via angle-resolved second harmonic scattering

Jan Dedic, Sandra Rocha, Pernilla Wittung Stafshede et al

Other conference contribution

2018

Alpha-Synuclein Modulates the Physical Properties of DNA

Kai Jiang, Sandra Rocha, Alvina Westling et al

Chemistry - A European Journal. Vol. 24 (58), p. 15685-15690

Journal article

2018

Flow Alignment of Extracellular Vesicles: Structure and Orientation of Membrane-Associated Bio-macromolecules Studied with Polarized Light

Imola Cs Szigyártó, Róbert Deák, Judith Mihály et al

ChemBioChem. Vol. 19 (6), p. 545-551

Journal article

2018

In vitro analysis of α-synuclein amyloid formation and cross-reactivity

Istvan Horvath, Sandra Rocha, Pernilla Wittung Stafshede

Methods in Molecular Biology. Vol. 1779, p. 73-83

Book chapter

2018

The processes of α-synuclein amyloid protein complexes involved in the pathogenesis of Parkinson’s disease

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al

Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. Vol. 118 (8), p. 75-81

Journal article

2017

Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al

Quarterly Reviews of Biophysics. Vol. 50, p. 1-9

Journal article

2017

Lipid membranes catalyse the fibril formation of the amyloid-? (1–42) peptide through lipid-fibril interactions that reinforce secondary pathways

David Lindberg, Emelie Vilhelmsson Wesén, Johan Björkeroth et al

Biochimica et Biophysica Acta - Biomembranes. Vol. 1859 (10), p. 1921-1929

Journal article

2017

Bayesian Analysis of MicroScale Thermophoresis Data to Quantify Affinity of Protein: Protein Interactions with Human Survivin

Maria-Jose Garcia-Bonete, Maja Jensen, Christian V. Recktenwald et al

Scientific Reports. Vol. 7 (1), p. Art. no. 16816-

Journal article

2017

A stretched conformation of DNA with a biological role?

Niklas Bosaeus, Anna Reymer, Tamas Beke-Somfai et al

Quarterly Reviews of Biophysics. Vol. 50, p. UNSP e11-e11

Journal article

2017

Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics

Ranjeet Kumar, Candan Ariöz, Yaozong Li et al

Biometals. Vol. 30 (1), p. 27-35

Journal article

2016

Probing Microscopic Orientation in Membranes by Linear Dichroism

Sandra Rocha, Maxim Kogan, Tamas Beke-Somfai et al

Langmuir. Vol. 32 (12), p. 2841-2846

Journal article

2016

Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer's disease treatment

J. A. Loureiro, Bárbara Gomes, Gert Fricker et al

Colloids and Surfaces B: Biointerfaces. Vol. 145, p. 8-13

Journal article

2016

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

Timothy R Sampson, Justine W Debelius, Taren Thron et al

Cell. Vol. 167 (6), p. 1469-1480.e12

Journal article

2015

Synthesis and study of the complex formation of a cationic alkyl-chain bola amino alcohol with DNA: in vitro transfection efficiency

D. Paiva, T. Markowski, B. Dobner et al

Colloid and Polymer Science. Vol. 293 (11), p. 3167-3175

Journal article

2015

Dual ligand immunoliposomes for drug delivery to the brain

J. A. Loureiro, Bárbara Gomes, Gert Fricker et al

Colloids and Surfaces B: Biointerfaces. Vol. 134, p. 213-219

Journal article

2015

Immunoliposomes doubly targeted to transferrin receptor and to α-synuclein

J. A. Loureiro, Bárbara Gomes, M. A. N. Coelho et al

Future Science OA. Vol. 1 (4)

Journal article

2014

Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies

J. A. Loureiro, Bárbara Gomes, M. A. N. Coelho et al

Nanomedicine. Vol. 9 (5), p. 709-722

Review article

2014

Enhancing Proteasome-Inhibitor Effect by Functionalized Gold Nanoparticles

S. C. Coelho, Sandra Rocha, M. C. Pereira et al

Journal of Biomedical Nanotechnology. Vol. 10 (4), p. 717-723

Journal article

2014

Enhanced Cellular Uptake of Antisecretory Peptide AF-16 through Proteoglycan Binding

Maria Matson Dzebo, Anna Reymer, Kristina Fant et al

Biochemistry. Vol. 53 (41), p. 6566-6573

Journal article

2014

Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers

S. C. Coelho, Sandra Rocha, P. Sampaio et al

Journal of Nanoparticle Research. Vol. 16 (4)

Journal article

2014

Fluorinated beta-sheet breaker peptides

J. A. Loureiro, R. Crespo, H. Borner et al

Journal of Materials Chemistry B. Vol. 2 (16), p. 2259-2264

Journal article

2014

Orientation of aromatic residues in amyloid cores: Structural insights into prion fiber diversity

Anna Reymer, K. K. Frederick, Sandra Rocha et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 111 (48), p. 17158-17163

Journal article

2014

Shear-Induced Membrane Fusion in Viscous Solutions

Maxim Kogan, Bobo Feng, Bengt Nordén et al

Langmuir. Vol. 30 (17), p. 4875-4878

Journal article

2013

Chitosan conjugates for DNA delivery

D. Paiva, G. Ivanova, M. C. Pereira et al

Physical Chemistry Chemical Physics. Vol. 15 (28), p. 11893-11899

Journal article

2013

Gold nanoparticle delivery-enhanced proteasome inhibitor effect in adenocarcinoma cells

S. C. Coelho, Sandra Rocha, P. Juzenas et al

Expert Opinion on Drug Delivery. Vol. 10 (10), p. 1345-1352

Journal article

2013

Targeted Drug Delivery Across the Blood Brain Barrier in Alzheimer's Disease

Sandra Rocha

Current Pharmaceutical Design. Vol. 19 (37), p. 6635-6646

Journal article

2013

Proteasome inhibitor delivery by functionalized gold nanoparticles in pancreatic cancer cells

S. C. Coelho, Sandra Rocha, M. C. Pereira et al

European Biophysics Journal. Vol. 42, p. S74-S74

Magazine article

2013

Carbon-core silver-shell nanodots as sensitizers for phototherapy and radiotherapy

A. Kleinauskas, Sandra Rocha, S. Sahu et al

Nanotechnology. Vol. 24 (32)

Journal article

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Showing 2 research projects

2021–2023

DNA recognition mechanisms

Bengt Nordén Chemistry and Biochemistry

Bobo Feng Chemistry and Biochemistry

Tamas Beke-Somfai Chemistry and Biochemistry

Sandra Rocha Chemical Biology

Per Lincoln Chemistry and Chemical Engineering

Swedish Research Council (VR)

2019–2021

Mechanism underlying the interaction of the Parkinson's disease protein, alpha-synuclein, with lipid membranes

Sandra Rocha Chemical Biology

Pernilla Wittung Stafshede Chemical Biology

Demensförbundet

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