Sandra Rocha

Researcher at Chalmers, Biology and Biological Engineering, Chemical Biology

Sandra Rocha studies protein structure, protein aggregation and protein interaction with lipid membranes using biophysical techniques. The proteins studied include alpha-synuclein, whose aggregation has been associated to Parkinson’s disease, and metalloproteins.

Source: chalmers.se

Showing 28 publications

2019

Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Kai Jiang, Sandra Rocha, Alvina Westling et al
Biophysical Journal
Paper in proceedings
2018

The processes of α-synuclein amyloid protein complexes involved in the pathogenesis of Parkinson’s disease

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. Vol. 118 (8), p. 75-81
Journal article
2018

Alpha-Synuclein Modulates the Physical Properties of DNA

Kai Jiang, Sandra Rocha, Alvina Westling et al
Chemistry - A European Journal. Vol. 24 (58), p. 15685-15690
Journal article
2018

In vitro analysis of α-synuclein amyloid formation and cross-reactivity

Istvan Horvath, Sandra Rocha, Pernilla Wittung Stafshede
Methods in Molecular Biology, p. 73-83
Book chapter
2018

Flow Alignment of Extracellular Vesicles: Structure and Orientation of Membrane-Associated Bio-macromolecules Studied with Polarized Light

Imola Cs Szigyártó, Róbert Deák, Judith Mihály et al
ChemBioChem. Vol. 19 (6), p. 545-551
Journal article
2017

Lipid membranes catalyse the fibril formation of the amyloid-? (1–42) peptide through lipid-fibril interactions that reinforce secondary pathways

David Lindberg, Emelie Vilhelmsson Wesén, Johan Björkeroth et al
Biochimica et Biophysica Acta - Biomembranes. Vol. 1859 (10), p. 1921-1929
Journal article
2017

Bayesian Analysis of MicroScale Thermophoresis Data to Quantify Affinity of Protein: Protein Interactions with Human Survivin

Maria-Jose Garcia-Bonete, Maja Jensen, Christian V. Recktenwald et al
Scientific Reports. Vol. 7 (1), p. Art. no. 16816-
Journal article
2017

A stretched conformation of DNA with a biological role?

Niklas Bosaeus, Anna Reymer, Tamas Beke-Somfai et al
Quarterly Reviews of Biophysics. Vol. 50, p. UNSP e11-
Journal article
2017

Unraveling amyloid formation paths of Parkinson's disease protein alpha-synuclein triggered by anionic vesicles

Juris Kiskis, Istvan Horvath, Pernilla Wittung Stafshede et al
Quarterly Reviews of Biophysics. Vol. 50, p. 1-9
Journal article
2016

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

Timothy R Sampson, Justine W Debelius, Taren Thron et al
Cell. Vol. 167 (6), p. 1469-1480.e12
Journal article
2016

Probing Microscopic Orientation in Membranes by Linear Dichroism

Sandra Rocha, Maxim Kogan, Tamas Beke-Somfai et al
Langmuir. Vol. 32 (12), p. 2841-2846
Journal article
2016

Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer's disease treatment

J. A. Loureiro, Bárbara Gomes, Gert Fricker et al
Colloids and Surfaces B: Biointerfaces. Vol. 145, p. 8-13
Journal article
2016

Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.

Ranjeet Kumar, Candan Ariöz, Yaozong Li et al
Biometals (1), p. 27-35
Journal article
2015

Synthesis and study of the complex formation of a cationic alkyl-chain bola amino alcohol with DNA: in vitro transfection efficiency

D. Paiva, T. Markowski, B. Dobner et al
Colloid and Polymer Science. Vol. 293 (11), p. 3167-3175
Journal article
2015

Immunoliposomes doubly targeted to transferrin receptor and to alpha-synuclein

J. A. Loureiro, Bárbara Gomes, M. A. N. Coelho et al
FUTURE SCIENCE OA. Vol. 1 (4)
Journal article
2015

Dual ligand immunoliposomes for drug delivery to the brain

J. A. Loureiro, Bárbara Gomes, Gert Fricker et al
Colloids and Surfaces B: Biointerfaces. Vol. 134, p. 213-219
Journal article
2014

Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies

J. A. Loureiro, Bárbara Gomes, M. A. N. Coelho et al
Nanomedicine. Vol. 9 (5), p. 709-722
Journal article
2014

Shear-Induced Membrane Fusion in Viscous Solutions

Maxim Kogan, Bobo Feng, Bengt Nordén et al
Langmuir. Vol. 30 (17), p. 4875-4878
Journal article
2014

Enhanced Cellular Uptake of Antisecretory Peptide AF-16 through Proteoglycan Binding

Maria Matson Dzebo, Anna Reymer, Kristina Fant et al
Biochemistry. Vol. 53 (41), p. 6566-6573
Journal article
2014

Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers

S. C. Coelho, Sandra Rocha, P. Sampaio et al
Journal of Nanoparticle Research. Vol. 16 (4)
Journal article
2014

Fluorinated beta-sheet breaker peptides

J. A. Loureiro, R. Crespo, H. Borner et al
Journal of Materials Chemistry B. Vol. 2 (16), p. 2259-2264
Journal article
2014

Orientation of aromatic residues in amyloid cores: Structural insights into prion fiber diversity

Anna Reymer, K. K. Frederick, Sandra Rocha et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 111 (48), p. 17158-17163
Journal article
2014

Enhancing Proteasome-Inhibitor Effect by Functionalized Gold Nanoparticles

S. C. Coelho, Sandra Rocha, M. C. Pereira et al
Journal of Biomedical Nanotechnology. Vol. 10 (4), p. 717-723
Journal article
2013

Targeted Drug Delivery Across the Blood Brain Barrier in Alzheimer's Disease

Sandra Rocha
Current Pharmaceutical Design. Vol. 19 (37), p. 6635-6646
Journal article
2013

Chitosan conjugates for DNA delivery

D. Paiva, G. Ivanova, M. C. Pereira et al
Physical Chemistry Chemical Physics. Vol. 15 (28), p. 11893-11899
Journal article
2013

Gold nanoparticle delivery-enhanced proteasome inhibitor effect in adenocarcinoma cells

S. C. Coelho, Sandra Rocha, P. Juzenas et al
Expert Opinion on Drug Delivery. Vol. 10 (10), p. 1345-1352
Journal article
2013

Proteasome inhibitor delivery by functionalized gold nanoparticles in pancreatic cancer cells

S. C. Coelho, Sandra Rocha, M. C. Pereira et al
European Biophysics Journal. Vol. 42, p. S74-S74
Magazine article
2013

Carbon-core silver-shell nanodots as sensitizers for phototherapy and radiotherapy

A. Kleinauskas, Sandra Rocha, S. Sahu et al
Nanotechnology. Vol. 24 (32)
Journal article

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