Elevated antibody reactivity to measles virus Ncore protein among patients with multiple sclerosis and their healthy siblings with intrathecal oligoclonal immunoglobulin G production
Journal article, 2014
Patients with multiple sclerosis (MS) and their healthy siblings with the MS oligoclonal bands (OCB) trait, (a hyperimmune condition in form of two or more CSF enriched OCBs) harbor in cerebrospinal fluid (CSF) and serum elevated immunoglobulin G (IgG) titers against measles crude whole-cell antigen. The underlying mechanism resulting in the increased IgG antibody reactivity to measles remains unclear. The response may represent specific IgG reactivity to measles antigens or unspecific auto-antibodies targeting cellular components in the crude whole virus antigens commonly used in detection assays.
likvor
mässlingvirus
oligoklonala band
antikroppar
multipel skleros
MS OCB trait
Author
Linn Persson
University of Gothenburg
Sonia Longhi
Aix Marseille University
Johanna Enarsson
University of Gothenburg
Oluf Andersen
University of Gothenburg
Sara Haghighi
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Martin Lagging
University of Gothenburg
Maria Johansson
University of Gothenburg
Tomas Bergström
University of Gothenburg
Journal of Clinical Virology
1386-6532 (ISSN) 18735967 (eISSN)
Vol. 61 1 107-112Subject Categories
Clinical Medicine
Neurology
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1016/j.jcv.2014.06.011