Elevated antibody reactivity to measles virus Ncore protein among patients with multiple sclerosis and their healthy siblings with intrathecal oligoclonal immunoglobulin G production
Artikel i vetenskaplig tidskrift, 2014
Patients with multiple sclerosis (MS) and their healthy siblings with the MS oligoclonal bands (OCB) trait, (a hyperimmune condition in form of two or more CSF enriched OCBs) harbor in cerebrospinal fluid (CSF) and serum elevated immunoglobulin G (IgG) titers against measles crude whole-cell antigen. The underlying mechanism resulting in the increased IgG antibody reactivity to measles remains unclear. The response may represent specific IgG reactivity to measles antigens or unspecific auto-antibodies targeting cellular components in the crude whole virus antigens commonly used in detection assays.
likvor
mässlingvirus
oligoklonala band
antikroppar
multipel skleros
MS OCB trait
Författare
Linn Persson
Göteborgs universitet
Sonia Longhi
Aix-Marseille Université
Johanna Enarsson
Göteborgs universitet
Oluf Andersen
Göteborgs universitet
Sara Haghighi
Göteborgs universitet
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Matematisk statistik
Martin Lagging
Göteborgs universitet
Maria Johansson
Göteborgs universitet
Tomas Bergström
Göteborgs universitet
Journal of Clinical Virology
1386-6532 (ISSN) 18735967 (eISSN)
Vol. 61 1 107-112Ämneskategorier
Klinisk medicin
Neurologi
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.1016/j.jcv.2014.06.011