Elevated antibody reactivity to measles virus Ncore protein among patients with multiple sclerosis and their healthy siblings with intrathecal oligoclonal immunoglobulin G production
Artikel i vetenskaplig tidskrift, 2014

Patients with multiple sclerosis (MS) and their healthy siblings with the MS oligoclonal bands (OCB) trait, (a hyperimmune condition in form of two or more CSF enriched OCBs) harbor in cerebrospinal fluid (CSF) and serum elevated immunoglobulin G (IgG) titers against measles crude whole-cell antigen. The underlying mechanism resulting in the increased IgG antibody reactivity to measles remains unclear. The response may represent specific IgG reactivity to measles antigens or unspecific auto-antibodies targeting cellular components in the crude whole virus antigens commonly used in detection assays.

likvor

mässlingvirus

oligoklonala band

antikroppar

multipel skleros

MS OCB trait

Författare

Linn Persson

Göteborgs universitet

Sonia Longhi

Aix Marseille Université

Johanna Enarsson

Göteborgs universitet

Oluf Andersen

Göteborgs universitet

Sara Haghighi

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Martin Lagging

Göteborgs universitet

Maria Johansson

Göteborgs universitet

Tomas Bergström

Göteborgs universitet

Journal of Clinical Virology

1386-6532 (ISSN)

Vol. 61 1 107-112

Ämneskategorier

Klinisk medicin

Neurologi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1016/j.jcv.2014.06.011