Localized controlled drug delivery from mesoporous implants
Paper in proceedings, 2014

Mesoporous materials possess both a well-defined topography on the nanometer scale, and they may serve as hosts for drugs. In this work, titanium implants coated with mesoporous TiO2 thin films have been evaluated both in vitro and in vivo. Material characterization showed that, long-range ordered mesoporous TiO2, with a pore-size of 6 nm, and a narrow pore-size distribution were obtained. An in vivo study demonstrated that the films were robust enough to withstand the implantation procedure. The in vitro apatite formation experiments showed that formation of apatite was higher on the mesoporous surface compared to its nonporous counterpart. In a separate in vivo study, two osteoporosis drugs, alendronate (ALN) and raloxifene (RLX), were immobilised into the nanoporous oxide films. The in vitro drug release tests carried out showed a sustained release of both drugs. The osteogenic response after 28 days of implantation of the drug-loaded implants showed a significantly improved bone fixation.

Author

Johan Karlsson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Necati Harmankaya

University of Gothenburg

Anders Palmquist

University of Gothenburg

Ryo Jimbo

Anna Martinelli

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Gustav Sundell

Chalmers, Applied Physics, Materials Microstructure

Mattias Thuvander

Chalmers, Applied Physics, Materials Microstructure

Mats Halvarsson

Chalmers, Applied Physics, Materials Microstructure

Pentti Tengvall

University of Gothenburg

Martin Andersson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014. Washington, DC, United States, 15-18 June 2014

Vol. 2 250-253

Subject Categories

Chemical Sciences

ISBN

978-1-4822-5827-1

More information

Created

10/7/2017