Localized controlled drug delivery from mesoporous implants
Paper i proceeding, 2014

Mesoporous materials possess both a well-defined topography on the nanometer scale, and they may serve as hosts for drugs. In this work, titanium implants coated with mesoporous TiO2 thin films have been evaluated both in vitro and in vivo. Material characterization showed that, long-range ordered mesoporous TiO2, with a pore-size of 6 nm, and a narrow pore-size distribution were obtained. An in vivo study demonstrated that the films were robust enough to withstand the implantation procedure. The in vitro apatite formation experiments showed that formation of apatite was higher on the mesoporous surface compared to its nonporous counterpart. In a separate in vivo study, two osteoporosis drugs, alendronate (ALN) and raloxifene (RLX), were immobilised into the nanoporous oxide films. The in vitro drug release tests carried out showed a sustained release of both drugs. The osteogenic response after 28 days of implantation of the drug-loaded implants showed a significantly improved bone fixation.

Författare

Johan Karlsson

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Necati Harmankaya

Göteborgs universitet

Anders Palmquist

Göteborgs universitet

Ryo Jimbo

Anna Martinelli

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Gustav Sundell

Chalmers, Teknisk fysik, Materialens mikrostruktur

Mattias Thuvander

Chalmers, Teknisk fysik, Materialens mikrostruktur

Mats Halvarsson

Chalmers, Teknisk fysik, Materialens mikrostruktur

Pentti Tengvall

Göteborgs universitet

Martin Andersson

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014. Washington, DC, United States, 15-18 June 2014

Vol. 2 250-253

Ämneskategorier

Kemi

ISBN

978-1-4822-5827-1