Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children.
Journal article, 2014
Pneumococcal serotypes are represented by a varying number of clonal lineages with different genetic contents, potentially affecting invasiveness. However, genetic variation within the same genetic lineage may be larger than anticipated.
Antigens
Pneumococcal Infections
Humans
genetics
Carrier State
Streptococcus Phages
Child
Disease Models
Genome
pathology
Child
genetics
Genotype
isolation & purification
Virulence
microbiology
Bacterial
Animal
Genetic Variation
Infant
DNA
epidemiology
epidemiology
Mice
classification
Membrane Proteins
Inbred C57BL
Gel
microbiology
Electrophoresis
Molecular Typing
genetics
Bacterial
Male
analysis
Sequence Analysis
Animals
Pulsed-Field
Female
Mice
analysis
Streptococcus pneumoniae
Adolescent
Preschool
Prophages
Author
Sarah Browall
Martin Norman
Jeanette Tångrot
Ilias Galanis
Karin Sjöström
Jessica Dagerhamn
Christel Hellberg
Anuj Pathak
Tiziana Spadafina
Andreas Sandgren
Patrick Bättig
Oscar Franzén
Björn Andersson
Åke Örtqvist
Staffan Normark
Birgitta Henriques-Normark
Journal of Infectious Diseases
0022-1899 (ISSN) 1537-6613 (eISSN)
Vol. 209 3 377-88Subject Categories
Pediatrics
Infectious Medicine
DOI
10.1093/infdis/jit481
PubMed
24009156