The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation.
Journal article, 2014
Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.
NBAT-1
NBAT1
Epigenetics
Neuroblastoma
NBAT
long noncoding RNA
Author
Gaurav Kumar Pandey
University of Gothenburg
Sanhita Mitra
University of Gothenburg
Santhilal Subhash
University of Gothenburg
Falk Hertwig
Meena Kanduri
University of Gothenburg
Kankadeb Mishra
University of Gothenburg
Susanne Fransson
University of Gothenburg
Abiarchana Ganeshram
University of Gothenburg
Tanmoy Mondal
University of Gothenburg
Sashidar Bandaru
University of Gothenburg
Malin Östensson
University of Gothenburg
Levent Akyürek
University of Gothenburg
Jonas Abrahamsson
Susan Pfeifer
E. G. Larsson
University of Gothenburg
Leming Shi
Zhiyu Peng
Matthias Fischer
Tommy Martinsson
University of Gothenburg
Fredrik Hedborg
Per Kogner
Chandrasekhar Kanduri
University of Gothenburg
Cancer Cell
1535-6108 (ISSN)
Vol. 26 5 722-737Subject Categories
Biochemistry and Molecular Biology
DOI
10.1016/j.ccell.2014.09.014
PubMed
25517750