The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation.
Artikel i vetenskaplig tidskrift, 2014

Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.

NBAT-1

NBAT1

Epigenetics

Neuroblastoma

NBAT

long noncoding RNA

Författare

Gaurav Kumar Pandey

Göteborgs universitet

Sanhita Mitra

Göteborgs universitet

Santhilal Subhash

Göteborgs universitet

Falk Hertwig

Meena Kanduri

Göteborgs universitet

Kankadeb Mishra

Göteborgs universitet

Susanne Fransson

Göteborgs universitet

Abiarchana Ganeshram

Göteborgs universitet

Tanmoy Mondal

Göteborgs universitet

Sashidar Bandaru

Göteborgs universitet

Malin Östensson

Göteborgs universitet

Levent Akyürek

Göteborgs universitet

Jonas Abrahamsson

Susan Pfeifer

E. G. Larsson

Göteborgs universitet

Leming Shi

Zhiyu Peng

Matthias Fischer

Tommy Martinsson

Göteborgs universitet

Fredrik Hedborg

Per Kogner

Chandrasekhar Kanduri

Göteborgs universitet

Cancer Cell

1535-6108 (ISSN)

Vol. 26 722-737

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1016/j.ccell.2014.09.014

PubMed

25517750