The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation.
Artikel i vetenskaplig tidskrift, 2014
Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.
NBAT-1
NBAT1
Epigenetics
Neuroblastoma
NBAT
long noncoding RNA
Författare
Gaurav Kumar Pandey
Göteborgs universitet
Sanhita Mitra
Göteborgs universitet
Santhilal Subhash
Göteborgs universitet
Falk Hertwig
Meena Kanduri
Göteborgs universitet
Kankadeb Mishra
Göteborgs universitet
Susanne Fransson
Göteborgs universitet
Abiarchana Ganeshram
Göteborgs universitet
Tanmoy Mondal
Göteborgs universitet
Sashidar Bandaru
Göteborgs universitet
Malin Östensson
Göteborgs universitet
Levent Akyürek
Göteborgs universitet
Jonas Abrahamsson
Susan Pfeifer
E. G. Larsson
Göteborgs universitet
Leming Shi
Zhiyu Peng
Matthias Fischer
Tommy Martinsson
Göteborgs universitet
Fredrik Hedborg
Per Kogner
Chandrasekhar Kanduri
Göteborgs universitet
Cancer Cell
1535-6108 (ISSN)
Vol. 26 5 722-737Ämneskategorier
Biokemi och molekylärbiologi
DOI
10.1016/j.ccell.2014.09.014
PubMed
25517750