Enhanced bone healing around nanohydroxyapatite-coated polyetheretherketone implants: An experimental study in rabbit bone
Journal article, 2014

Objective To investigate the bone response to threaded polyetheretherketone (PEEK) implants coated with nanohydroxyapatite. Materials and methods A total of 39 PEEK implants were coated with nanocrystalline hydroxyapatite and 39 uncoated implants were used as controls. The implant surface was characterized by optical interferometry and scanning electron microscope. The implants were inserted in the tibia and femur of 13 rabbits. After 6 weeks of healing, quantitative and qualitative analyses were performed. Results The test implants showed significantly higher removal torque test values compared with the control group. Histomorphometric evaluation demonstrated higher bone-to-implant contact for the test implants; however, there were no differences in bone area between the groups. Qualitative histological analyses demonstrated inflammatory cellular reactions in close vicinity of both implant surfaces. A two-cell layer of foreign body giant cells was observed irrespective of sample type. Conclusion Our findings demonstrate that implants with a threaded design render good stability to PEEK in both coated and uncoated implants. Nanohydroxyapatite-coated PEEK implants demonstrated improved bone formation compared with uncoated controls.


Sargon Barkarmo

University of Gothenburg

Martin Andersson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Fredrik Currie

Promimic AB

Per Kjellin

Promimic AB

Ryo Jimbo

Malmö university

Carina B. Johansson

University of Gothenburg

Victoria Franke Stenport

University of Gothenburg

Journal of Biomaterials Applications

0885-3282 (ISSN)

Vol. 29 5 737-747

Subject Categories

Basic Medicine

Materials Engineering

Biological Sciences





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Latest update

9/6/2018 1