Acute escitalopram but not contextual conditioning exerts a stronger "anxiogenic" effect in rats with high baseline "anxiety" in the acoustic startle paradigm.
Journal article, 2015
Acute administration of selective serotonin reuptake inhibitors (SSRIs) may enhance anxiety in humans, those with anxiety disorders being more susceptible than others. Fear-conditioned or unconditioned acoustic startle and freezing are common measures of fear and/or "anxiety" in rodents that may be used to study this effect of SSRIs preclinically.
Author
Robert Pettersson
University of Gothenburg
Jakob Näslund
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Elias Eriksson
University of Gothenburg
S Melker Hagsäter
University of Gothenburg
Psychopharmacology
0033-3158 (ISSN) 14322072 (eISSN)
Vol. 232 8 1461-1469Subject Categories
Pharmaceutical Sciences
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1007/s00213-014-3783-z
PubMed
25417552